Background: Tuberculosis (TB) remains the most frequent and important infectious disease causing morbidity and mortality globally. The World Health Organization estimates the incidence of all forms of TB in Zambia at 444/100,000. Tuberculosis case notification rates have increased eightfold over the past two decades and this is largely due to the concurrent Human Immunodeficiency Virus epidemic. The cornerstone of Tuberculosis control is early case detection and treatment which is promoted by Direct Observed Treatment-Short course strategy. This paper reviews the available information in English on TB situation in Ndola district of Zambia with the purpose of assessing successes recorded over the reviewed period. Results: This review has noted a reduction in the number of new cases of TB recorded, improved diagnosis and treatment success of TB in Ndola district over the reviewed period. Conclusion: This review has observed a reduction in the number of new cases of TB recorded in Ndola district over a period of ten years due to the strategies put up by the National TB Program as well as the effective implementation of the strategies by the District Medical team. These strategies included the Directly Observed Therapy Short course (DOTS).
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