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uhrf1与肿瘤

Keywords: 泛素样含phd和环指域1,核蛋白基因,肿瘤,放化疗抗拒

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Abstract:

?泛素样含phd和环指域1(ubiquitin-likewithphdandringfingerdomains1,uhrf1)是新发现的一种与细胞生长有关的核蛋白基因,参与了细胞增殖、周期调控、凋亡及放射敏感性等重要的生物学过程。并且在多种肿瘤细胞中异常高表达,与肿瘤的发生、发展、侵袭转移及放化疗抵抗关系密切,可能成为肿瘤基因治疗的一个新靶点。本文就uhrf1与肿瘤的关系作一简要综述。

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