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OALib Journal期刊
ISSN: 2333-9721
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银莲花素a对非小细胞肺癌h460的抑制作用
DOI: 10.3724/SP.J.1145.2010.00637, PP. 637-641
Keywords: 银莲花素a,肺癌细胞h460,细胞增殖,细胞凋亡,细胞周期
Abstract:
通过溶剂萃取与重结晶等方法从银莲花属植物多被银莲花anemoneraddeanaregel根茎中提取三萜皂苷银莲花素a，研究银莲花素a对非小细胞肺癌h460癌细胞的增殖、凋亡与细胞周期的影响及分子机制.结果表明：银莲花素a能显著地抑制h460癌细胞的增殖，且这种抑制效应呈明显的时间量效关系；能诱导h460癌细胞凋亡，并诱导其细胞周期阻滞于g2-m期；能抑制akt激酶活性、下调bcl-2蛋白表达以及激活parp活性，从而导致其对h460癌细胞的增殖抑制作用.结果显示银莲花素a对非小细胞肺癌的预防与治疗可能具有潜在价值.图5参21
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