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OALib Journal期刊
ISSN: 2333-9721
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异丙酚和异氟醚对急性颅脑外伤手术患者血清神经元烯醇化酶变化的比较
, PP. 858-860
Keywords: 异丙酚,异氟醚,颅脑外伤,神经元烯醇化酶
Abstract:
目的研究急性颅脑外伤手术前和手术期间的血清神经元烯醇化酶(nse)的变化及异丙酚和异氟醚对这一变化的影响。方法10例泌尿系统手术的非颅脑损伤患者为正常对照组,以酶联免疫吸附方法测定术前血清nse含量。急症颅脑外伤手术患者30例,随机分为异丙酚组(a组)和异氟醚组(b组),每组15例。两组患者分别于手术前、手术2h、手术结束时测定血清nse含量。对急症颅脑外伤手术患者进行格拉斯哥评分并记录。结果脑外伤病人手术前nse显著高于正常对照组(p<0.01),哥拉斯哥评分越低的病人术前nse越高(r=-0.494,p<0.01);手术结束时异丙酚组nse显著低于异氟醚组(p<0.05);开颅手术2h和手术结束时两组nse均较术前升高。结论急性颅脑外伤时患者血清nse浓度是升高的,颅脑损伤越重,血清nse浓度越高。开颅手术期间持续静脉泵注临床麻醉剂量的异丙酚可减轻继发性脑损害,降低血清nse浓度的升高,具有脑保护作用,是颅脑手术麻醉的理想药物。
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