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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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慢性体外反搏对高胆固醇血症猪动脉内皮细胞的影响
, PP. 1491-1493
Keywords: 增强体外反搏,高胆固醇血症,内皮细胞,蛋白质组学,形态学
Abstract:
目的探讨慢性增强型体外反博(eecp)能否在体修复高胆固醇血症引起的猪动脉内皮细胞(ecs)损伤。方法高胆固醇血症猪反搏36h后,取前降支进行扫描电镜检查,收集胸主动脉ecs进行蛋白质组学检查。结果高脂组冠脉ecs排列不规则、大量脱落、斑块形成,反搏组ecs呈流线型排列、脱落程度显著减轻;与高脂组相比,在反搏组的ecs检测到6种高表达的蛋白。结论慢性eecp可能通过调节ecs蛋白表达,改善ecs粘附性和代谢及减轻ecs内皮凋亡,从而修复高胆固醇血症对动脉内皮形态和功能的损伤。
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