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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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紫杉醇联合herceptin或表阿霉素治疗her-2/neu阳性乳腺癌患者的临床疗效
, PP. 1533-1536
Keywords: 乳腺癌,肿瘤标志物,herceptin,生物化疗,her-2/neu,紫杉醇,表阿霉素
Abstract:
目的比较herceptin联合紫杉醇(tax)的生物化疗组和表阿霉素(epi)联合tax单纯化疗组治疗her-2/neu阳性表达的乳腺癌患者的疗效评估以及前者血清肿瘤标志物的变化及意义。方法选择免疫组化法检查her-2/neu为阳性的乳腺癌患者为入选对象,以32例接受herceptin联合tax方案治疗者为研究组,41例接受epi联合tax方案治疗者为对照组,分别观察上述两组病人的疗效、研究组病人her-2/neu表达强度与疗效之间的关系及该组患者血清肿瘤标志物的变化。结果herceptin联合tax治疗乳腺癌的客观有效率(rr%)、临床受益率(rr+sd%)均明显高于epi联合tax组;生物化疗组中,免疫组化检测结果为her-2/neu(+)、her-2/neu(++)、her-2/neu(+++)的患者的临床有效率分别为0%、44.4%和63.6%;单纯化疗组分别为8.3%、36.4%和38.9%;herceptin联合tax方案化疗后,血清肿瘤标志物水平与化疗前比较有不同程度降低,ca153、tps及cea与治疗前相比有显著性差异(p<0.05),而ca125则无显著性差异(p>0.05)。结论对于her-2/neu阳性的晚期乳腺癌患者,herceptin联合tax方案组的疗效明显优于tax联合epi方案组,对her-2/neu(+++)的乳腺癌患者,herceptin联合tax治疗的有效率高于her-2/neu(++)的患者。肿瘤标志物cea、tps、ca153在判定疗效上也有一定的临床价值。
| [1] | 周爱萍.乳腺癌靶向治疗:herceptin的研究进展[j].国外医学？肿瘤学分册,2000,8(4):167-70.
|
| [2] | baselgaj,tripathyd,mendelsohnj,etal.phaseⅱstudyofweeklyintravenoustrastuzumab(herceptin)inpatientswithher-2/neuoverexpressingmetastaticbreastcancer[j].jclinoncol,1996,14(3):737-44.
|
| [3] | vogelcl,cobleighma,tripathyd,etal.first-lineherceptinmonotherapyinmetastaticbreastcancer[j].oncology,2001,61(suppl2):37-42.
|
| [4] | 宋海珠,罗荣城.herceptin治疗转移性乳腺癌的研究进展[j].中国肿瘤生物治疗杂志,2002,9(2):144-5.songhz,luorc.progressofthetherapyofmatestaticbreastcancerofherceptin[j].chinjcancerbiother,2002,9(2):144-5.
|
| [5] | fornierm,estevafj,seidmanad.trastuzumabincombinationwithchemotherapyforthetreatmentofmetastaticbreastcancer[j].seminoncol,2000,27(6suppl11):38-45.
|
| [6] | 孙燕,周际昌.临床肿瘤内科手册[m].第4版,北京:人民卫生出版社,2003.107-13.
|
| [7] | hayesdf,thorad.c-erbb-2inbreastcancer:developmentofaclinicallyusefulmarker[j].seminoncol,2002,29(3):231-45.
|
| [8] | aziza,pervezs,khans,etal.significanceofimmunohistohemicalc-erbb-2productlocalizationpatternforprognosisinhumanbreastcancer[j].patholoncolres,2001,7(3):190-6.
|
| [9] | baselgaj,nortonl,albanellj,etal.recombinanthumanizedanti-her2antibody(herceptin)enhancestheantitumoractivityofpaclitaxelanddoxorubicinagainsther2/neuoverexpressinghumanbreastcancerxenografts[j].cancerres,1998,58(13):2825-31.
|
| [10] | senapads,neungtons,thirapakawongc,etal.predictivevalueofthecombinedserumca125andtpsduringchemotherapyandbeforesecond-looklaparotomyinepithelialovariancancer[j].anticancerres,2000,20(2b):1297-300.
|
| [11] | 汤沼猷.现代肿瘤学[m].上海医科大学出版社,1993.3549.
|
| [12] | berrutia,tampellinim,tortam,etal.prognosticvalueinpredictingoverallsurvivaloftwomucinusmarkers:ca15-3andca125inbreastcancerpatientsatfirstrelapseofdisease[j].eurjcancer,1994,30a(14):2082-4.
|
| [13] | krammers,raffu,jagerw,etal.ca125asanindicatorofpleuralmetastasesinbreastcancer[j].anticancerres,1996,16(5b):3165-8.
|
| [14] | arjunmd,thomasmd,stevenpd.serumca125elevationandriskofclinicaldetectionofcancerinasymptomaticpostmenopausalwomen[j].cancer,1999,85(9):2068-72.
|
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