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脂质代谢组学的研究进展

DOI: 10.3969/j.issn.1006-267x.2011.11.004

Keywords: 脂质代谢组学,研究进展,调控

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Abstract:

脂质是动物体内重要的生物大分子之一,具有多种重要生物学功能。脂质代谢组学是新兴起的一门研究脂质代谢调控在各种生命现象中作用机制的新学科。它通过从系统水平上研究生物体内的脂质,揭示脂质分子及与其他生物分子间的相互作用。脂质代谢组学在营养学、功能基因组学等相关学科中的应用已有许多报道。本文主要介绍了脂质的分类与代谢、脂质代谢组学的概念、研究方法、研究现状及其应用研究进展等。

References

[1]  朱超,胡坪,梁琼麟,等.脂组学及其研究进展[J].分析化学,2009,37(9):1390-1396.
[2]  GRIFFIN J L,WALKER L A, GARROD S, et al. NMR spectroscopy based metabonomic studies on the comparative biochemistry of the kidney and urine of the bank vole (Clethrionomys glareolus), wood mouse (Apodemus sylvaticus), white toothed shrew (Crocidura suaveolens) and the laboratory rat[J]. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2000, 127(3):357-367.
[3]  NICHOLSON J K, WILSON I D. Understanding ‘Global’ systembiology: metabonomics and the continuum of metabolism[J]. Nature Review Drug Discovery, 2003, 2(4):668-677.
[4]  王涛,梅旭荣,钟秀丽,等.脂质组学研究方法及其应用[J].植物学报,2011,45(2):249-257.
[5]  TYURIN V A, TYURINA Y Y, KOCHANEK P M, et al. Oxidative lipidomics of programmed cell death[J]. Methods in Enzymology, 2008, 442(2):375-393.
[6]  BALAZY M. Eicosanomics: targeted lipidomics of eicosanoids in biological systems[J]. Prostaglandins & Other Lipid Mediators, 2004, 73(3/4):173-180.
[7]  LEE S H, WILLIAMS M V, BLAIR I A. Targeted chiral lipidomics analysis[J]. Prostaglandins Other Lipid Mediators, 2005, 77(1/2/3/4):141-157.
[8]  SERHAN C N. Mediator lipidomics[J]. Prostaglandins & Other Lipid Mediators, 2005, 77(1/2/3/4):4-14.
[9]  GROSS R W, JENKINS C M, YANG J, et al. Functional lipidomics: theroles of specialized lipids and lipid-protein interactions in modulating neuronal function[J]. Prostaglandins & Other Lipid Mediators, 2005, 77(1/2/3/4):52-64.
[10]  陆姝欢,杨松,元英进.脂质组学在医药研究中的应用[J].细胞生物学,2007,29(2):169-172.
[11]  蔡潭溪,刘平生,杨福全,等.脂质组学研究进展[J].生物化学与生物物理进展,2010,37(2):121-128.
[12]  PANG L Q, LIANG Q L, WANG Y M, et al. Simultaneous determination and quantification of seven major phospholipid classes in human blood using normal-phase liquid chromatography coupled with electrospray mass spectrometry and the application in diabetes nephropathy[J]. Journal of Chromatography B, 2008, 869(1/2):118-125.
[13]  谭力,鞠熀先,黎介寿,等.血清总磷脂脂肪酸组分的固相萃取-气相色谱法分析[J].分析科学学报,2006,22(2):125-128.
[14]  宋亚军,杨瑞馥.微生物学研究中的软电离质谱技术[J].生物技术通讯,2000,11(1):39-44,53.
[15]  KRAFT M L, WEBER P K, LONGO M L, et al. Phase separation of lipid membranes analyzed with high-resolution secondary ion mass spectrometry[J]. Science, 2006, 313:1948-1951.
[16]  VELAGAPUDI V R, HEZAVEH R, REIGSTAD C S, et al. The gut microbiota modulates host energy and lipid metabolism in mice[J]. Journal of Lipid Research, 2010, 51(5):1102-1112.

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