BURRIN D G,JANECZKO M J,STOLL B,et al.Emerging aspects of dietary glutamate metabolism in the developing gut[J].Asia Pacific Journal of Clinical Nutrition,2008,17:368-371.
[2]
HSU C B,HUANG H J,WANG C H,et al.The effect of glutamine supplement on small intestinal morphology and xylose absorptive ability of weaned piglet[J].African Journal of Biotechnology,2010,9:7003-7008.
[3]
KALKAN-UCAR S,COKER M,S？ZMEN E,et al.An association among iron,copper,zinc,and selenium,and antioxidative status in dyslipidemic pediatric patients with glycogen storage disease types IA and Ⅲ[J].Journal of Trace Elements in Medicine and Biology,2010,24:42-45.
[4]
CHAUHAN A,CHAUHAN V.Oxidative stress in autism[J].Pathophysiology,2006,13:171-181.
[5]
SPYROPOULOS B G,MISIAKOS E P,FOTIADIS C,et al.Antioxidant properties of probiotics and their protective effects in the pathogenesis of radiation-induced enteritis and colitis[J].Digestive Diseases and Sciences,2010,56:285-294.
[6]
ZHANG Y,DU R T,WANG L F,et al.The antioxidative effects of probiotic Lactobacillus casei Zhang on the hyperlipidemic rats[J].European Food Research and Technology,2010,231:151-158.
[7]
BROOKES P S.Mitochondrial H+ leak and ROS generation:an odd couple[J].Radical Biology and Medicine,2005,38:12-23.
[8]
BRUININX E M,VAN DER PEET-SCHWERING C M C,SCHRAMA J W.Individual feed intake of group-housed weaned pigs and health status[M]//VARLEY M A,WISEMAN J.The weaner pig nutrition and management.Wallingford:CAB International,2001:113-122.
[9]
INOGUCHI T,LI P,UMEDA F,et al.High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells[J].Diabetes,2000,49:1939-1945.
[10]
SCHRADER M,FAHIMI H D.Peroxisomes and oxidative stress[J].Biochimica et Biophysica Acta,2006,1763:1755-1766.
[11]
SCH？NFELD P,WOJTCZAK L.Fatty acids as modulators of the cellular production of reactive oxygen species[J].Free Radical Biology & Medicine,2008,45:231-241.
[12]
TANIDA S,MIZOSHITA T,MIZUSHIMA T,et al.Involvement of oxidative stress and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in inflammatory bowel disease[J].Journal of Clinical Biochemistry and Nutrition,2011,48:112-116.
[13]
ALTEHELD B,EVANS M E,GU L H,et al.Alanylglutamine dipeptide and growth hormone maintain pepT1-mediated transport in oxidatively stressed Caco-2 cells[J].The Journal of Nutrition,2005,135:19-26.
[14]
ASSIMAKOPOULOS S F,SCOPA C D,VAGIANOS C E.Pathophysiology of increased intestinal permeability in obstructive jaundice[J].World Journal of Gastroenterology,2007,48:6458-6464.
[15]
GUTTMAN J A,FINLAY B B.Tight junctions as targets of infectious agents[J].Biochimica et Biophysica Acta,2009,1788:832-841.
[16]
BALDA M S,MATTER K.Tight junctions at a glance[J].Journal of Cell Science,2008,121:3677-3682.
[17]
ELIAS B C,SUZUKI T,SETH A,et al.Phosphorylation of Tyr-398 and Tyr-402 in occludin prevents its interaction with ZO-1 and destabilizes its assembly at the tight junctions[J].The Journal of Biological Chemistry,2009,284:1559-1569.
[18]
KAWAUCHIYA T,TAKUMI R,KUDO Y,et al.Correlation between the destruction of tight junction by patulin treatment and increase of phosphorylation of ZO-1 in Caco-2 human colon cancer cells[J].Toxicology Letters,2011,205:196-202.
[19]
LISCHPER M,BEUCK S,THANABALASUNDARAM G,et al.Metalloproteinase mediated occludin cleavage in the cerebral microcapillary endothelium under pathological conditions[J].Brain Research,2010,1326:114-127.
[20]
GONZáLEZ-MARISCAL L,TAPIA R,CHAMORRO D,et al.Crosstalk of tight junction components with signaling pathways[J].Biochimica et Biophysica Acta,2008,1778:729-756.
[21]
GRANGER D N,VOWINKEL T,ETNEHAZY T P.Modulation of the inflammatory response in cardiovascular disease[J].Hypertension,2004,43:924-931.
[22]
KIMURA T,IWASE M,KONDO G,et al.Suppressive effect of selective cyclooxygenase-2 inhibitor on cytokine release in human neutrophils[J].International Immunopharmacology,2003,3:1519-1528.
[23]
BRZOZOWSKI T,KONTUREK P C,KONTUREK S J,et al.Implications of reactive oxygen species and cytokines in gastroprotection against stress-induced gastric damage by nitric oxide releasing aspirin[J].International Journal of Colorectal Disease,2003,18:320-329.
[24]
SACCANI A,SACCANI S,ORLANDO S.Redox regulation of chemokine receptor expression[J].Proceedings of the National Academy of Sciences,2000,97:2761-2766.
[25]
SINGH D K,KUMAR D,SIDDIQUI Z.The strength of receptor signaling is centrally controlled through a cooperative loop between Ca2+ and an oxidant signal[J].Cell,2005,121:281-293.
[26]
HE H T,LELLOUCH A,MARGUET D.Lipid rafts and the initiation of T cell receptor signaling[J].Seminars in Immunology,2005,17:23-33.
STEPHENSEN C B,MARQUIS G S,DOUGLAS S D,et al.Immune activation and oxidative damage in HIV-positive and HIV-negative adolescents[J].Journal of Acquired Immune Deficiency Syndromes,2005,38:180-190.
[29]
VIDALI M,STEWART S F,ALBANO E,et al.Interplay between oxidative stress and immunity in the progression of alcohol-mediated liver injury[J].Trends in Molecular Medicine,2007,14:63-71.
[30]
STEWART S F,VIDALI M,DAY C P,et al.Oxidative stress as a trigger for cellular immune responses in patients with alcoholic liver disease[J].Hepatology,2004,39:197-203.
[31]
MAES M,MIHAYLOVA I,LEUNIS J C.Chronic fatigue syndrome is accompanied by an IgM-related immune response directed against neoepitopes formed by oxidative or nitrosative damage to lipids and proteins[J].Neuroendocrinology Letters,2006,27:615-621.
BINGISSER R M,TILBROOK P A,HOLT P G,et al.Macrophage-derived nitric oxide regulates T cell activation via reversible disruption of the Jak3/STAT5 signaling pathway[J].The Journal of Immunology,1998,160:5729-5734.
[34]
TEZEL G,YANG X J,LUO C,et al.Oxidative stress and the regulation of complement activation in human glaucoma[J].Investigative Ophthalmology & Visual Science,2010,51:5071-5082.
[35]
LEE K,ESSELMAN W J.Inhibition of PTPs by H2O2 regulates the activation of distinct MAPK pathways[J].Free Radical Biology and Medicine,2002,33:1121-1132.
[36]
TOHYAMA Y,TAKANO T,YAMAMURA H B.Cell responses to oxidative stress[J].Current Pharmaceutical Design,2004,10:835-839.
[37]
DENG Q L,XU J,YU B.Effect of dietary tea polyphenols on growth performance and mediated immune response of postweaning piglets under oxidative stress[J].Archives of Animal Nutrition,2010,64:12-21.
[38]
KING M R,ISMAIL A S,DAVIS L S,et al.Oxidative stress promotes polarization of human T cell differentiation toward a T helper 2 phenotype[J].The Journal of Immunology,2006,176:2765-2772.
[39]
GUZIK T J,KORBUT R,ADAMEK-GUZIK T.Nitric oxide and superoxide in inflammation and immune regulation[J].Journal of Physiology and Pharmacology,2003,54:469-487.
[40]
CRAPO J D.Oxidative stress as an initiator of cytokine release and cell damage[J].European Respiratory Journal,2003,22:4-6.
[41]
MATALON S,DAVIS I C,LANG J D.Involvement of reactive oxygen and nitrogen species in the pathogenesis of acute lung injury[J].International Symposium on Intensive Care and Emergency Medicine,2007,44:97-111.
[42]
ROSSIGNOL D A.Hyperbaric oxygen treatment for inflammatory bowel disease:a systematic review and analysis[J].Medical Gas Research,2012,2:6.doi:10.1186/2045-9912-2-6.
[43]
LAKHAN S E,KIRCHGESSNER A.Neuroinflammation in inflammatory bowel disease[J].Journal of Neuroinflammation,2010,7:37.
[44]
CHEN X,ZUO Q,HAI Y D.Lactulose:an indirect antioxidant ameliorating inflammatory bowel disease by increasing hydrogen production[J].Medical Hypotheses,2010,76:325-327.
[45]
ZHU L H,ZHAO K L,CHEN X L,et al.Impact of weaning and an antioxidant blend on intestinal barrier function and antioxidant status in pigs[J].Journal of Animal Science,2012,90:2581-2589.
[46]
LALLèS J P.Nutrition and gut health of the young pig around weaning:what news?[J].Archiva Zootechnica,2008,11:5-15.
[47]
BOUDRY G,GUéRIN S,MALBERT C H.Effect of an abrupt switch from a milk-based to a fibre-based diet on gastric emptying rates in pigs:difference between origins of fibre[J].British Journal of Nutrition,2004,92:913-920.
[48]
LALLèS J P,BOUDRY G,FAVIER C,et al.Gut function and dysfunction in young pigs:physiology[J].Animal Research,2004,53:301-331.
[49]
LAURIDSEN C,JENSEN S K.Infiuence of supplementation of all-rac-tocopheryl acetate preweaning and vitamin C postweaning on alpha-tocopherol and immune responses of piglets[J].Journal of Animal Science,2005,83:1274-1286.
[50]
DOBROWOLSKI P,？LIWA E.The weaning-related changes in amino acids status of blood plasma in piglets[J].Journal of Pre-Clinical and Clinical Research,2008,2:71-74.
[51]
PETROVI？ V,NOVOTN Y J,HISIRA V,et al.The impact of suckling and post-weaning period on blood chemistry of piglets[J].Acta Veterinaria Brno,2009,78:365-371.
[52]
BILZER M.Glutathione treatment protects the rat liver against injury after warm ischemia and kupffer cell activation[J].Digestion,2002,66:49-57.
WANG J,CHEN L,LI P,et al.Gene expression is altered in piglet small intestine by weaning and dietary glutamine supplementation[J].The Journal of Nutrition,2008,138:1025-1032.
[56]
WHITE J S,HOPER M,PARKS R W,et al.Glutamine improves intestinal barrier function in experimental biliary obstruction[J].European Surgical Research,2005,37:342-347.
[57]
LI Y,CHEN Y,ZHANG J,et al.Protective effect of glutamine enriched early enteral nutrition on intestinal mucosal barrier injury after liver transplantation in rats[J].The American Journal of Surgery,2010,199:35-42.
[58]
CHAO J C,HUANG C H,WU S J,et al.Effects of β-carotene,vitamin C and E on antioxidant status in hyperlipidemic smokers[J].The Journal of Nutritional Biochemistry,2002,13:427-434.
[59]
LEVASTA B,MONTEB M,CHEVALEYREA C,et al.Ultra-early weaning in piglets results in low serum IgA concentration and IL17 mRNA expression[J].Veterinary Immunology and Immunopathology,2010,137:261-268.
[60]
SUN Y,YAO W,PEREZ-GUTIERREZ O N,et al.Changes in abundance of Lactobacillus spp. and Streptococcus suis in the stomach,jejunum and ileum of piglets after weaning[J].FEMS Microbiology Ecology,2008,66:548-555.
[61]
SUN J,HU X L,LE G W,et al.Lactobacilli prevent hydroxy radical production and inhibit Escherichia coli and Enterococcus growth in system mimicking colon fermentation[J].Letters in Applied Microbiology,2010,50:246-269.
[62]
KUNDU S D,LEE C,BILLIPS B K,et al.The toll-like receptor pathway:a novel mechanism of infection-induced carcinogenesis of prostate epithelial cells[J].Prostate,2008,68:223-229.
[63]
XIE C,KANG J,FERGUSON M E,et al.Blueberries reduce pro-inflammatory cytokine TNF-α and IL-6 production in mouse macrophages by inhibiting NF-κB activation and the MAPK pathway[J].Molecular Nutrition & Food Research,2011,55:1587-1591.
[64]
GLAYSHER M,ROACH H I.Nuclear factor-κB is involved in the signal transduction of cytokine-induce expression of IL-1 beta by human articular chondrocytes[J].The Journal of Bone & Joint Surgery,2009,93:22-23.
[65]
KANG S R,PARK K I,PARK H S,et al.Anti-inflammatory effect of flavonoids isolated from Korea Citrus aurantium L.on lipopolysaccharide-induced mouse macrophage RAW 264.7 cells by blocking of nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signalling pathways[J].Food Chemistry,2011,129:1721-1728.
[66]
PANG P M,RAAD H,DERKAWI R A,et al.The NADPH oxidase cytosolic component p67phox is constitutively phosphorylated in human neutrophils:regulation by a protein tyrosine kinase,MEK1/2 and phosphatases 1/2A[J].Biochemical Pharmacology,2011,82:1145-1152.
[67]
LE DIVIDICH J,SVE B.Effects of underfeeding during the weaning period on growth,metabolism,and hormonal adjustments in the piglet[J].Domestic Animal Endocrinology,2000,19:63-74.
[68]
MASON S P,JARVIS S,LAWRENCE A B.Individual differences in responses of piglets to weaning at different ages[J].Applied Animal Behaviour Science,2003,80:117-132.
[69]
CARROLL J A,ARTHINGTON J D,CHASE J C C.Early weaning alters the acute-phase reaction to an endotoxin challenge in beef calves[J].Journal of Animal Science,2009,87:4167-4172.
[70]
ALICIA J,KOWALTOWSKI N C.Mitochondria and reactive oxygen species[J].Free Radical Biology and Medicine,2009,47:333-343.
[71]
TAGAWA Y,HIRAMATSU N,KASAI A.et al.Induction of apoptosis by cigarette smoke via ROS-dependent endoplasmic reticulum stress and CCAAT/enhancer-binding protein-homologous protein (CHOP)[J].Free Radical Biology and Medicine,2008,45:50-59.
[72]
CIRCU M L,AW T Y.Reactive oxygen species,cellular redox systems,and apoptosis[J].Free Radical Biology and Medicine,2010,48:749-762.
[73]
YANG E S,WOO S M,CHOI K S,et al.Acrolein sensitizes human renal cancer Caki cells to TRAIL-induced apoptosis via ROS-mediated up-regulation of death receptor-5 (DR5) and down-regulation of Bcl-2[J].Experimental Cell Research,2011,317:2592-2601.
[74]
ROBERTSON R P,HARMON J,TRAN P O,et al.Glucose toxicity in beta-cells:type 2 diabetes,good radicals gone bad,and the glutathione connection[J].Diabetes,2003,52:581-587.
[75]
MENG Z,LV J,LUO Y,et al.Forkhead box O1/pancreatic and duodenal homeobox1 intracellular translocation is regulated by c-jun N-terminal kinase and involved in prostaglandin E2-induced pancreatic β-cell dysfunction[J].Endocrinology,2009,150:5284-5293.
[76]
TIGANIS T.Reactive oxygen species and insulin resistance:the good,the bad and the ugly[J].Trends in Pharmacological Sciences,2011,32:82-89.
[77]
PESSLER-COHEN D,PEKALA P H,KOVSAN J,et al.GLUT4 repression in response to oxidative stress is associated with reciprocal alterations in C/EPB alpha and delta isoforms in 3T3-L1 adipocytes[J].Archives of Insect Biochemistry and Physiology,2006,112:3-12.
[78]
FURUKAWA-HIBI T,KITAYAMA K,YAMASHITA H,et al.Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation[J].Biochemical Journal,2003,375:365-371.
[79]
FURUKAWA-HIBI Y,KOBAYASHI Y,CHEN C,et al.FOXO transcription factors in cell-cycle regulation and the response to oxidative stress[J].Antioxidants & Redox Signaling,2005,7:752-760.
[80]
BARTHEL A,SCHMOLL D,UNTERMAN T G.FoxO proteins in insulin action and metabolism[J].Trends in Endocrinology and Metabolism,2005,16:183-189.
[81]
LAURENCIKIENE J,VAN HARMELEN V,ARVIDSSON NORDSTRM E,et al.NF-κB is important for TNF-α-induced lipolysis in human adipocytes[J].The Journal of Lipid Research,2007,48:1069-1077.
[82]
RANJIT S,BOUTET E,GANDHI P,et al.Regulation of fat specific protein 27 by isoproterenol and TNF-α to control lipolysis in murine adipocytes[J].The Journal of Lipid Research,2011,52:221-236.
[83]
KAMEI Y,MIZUKAMI J,MIURA S A.Forkhead transcription factor FKHR up-regulates lipoprotein lipase expression in skeletal muscle[J].FEBS Letters,2003,536:232-236.
[84]
LI J J,ZHANG T P,MENG Y,et al.Stability of F-box protein atrogin-1 is regulated by p38 mitogen-activated protein kinase pathway in cardiac H9c2 cells[J].Cellular Physiology and Biochemistry,2011,27:463-470.
[85]
S？DERLUND J,ERHARDT S,KAST R E.Acyclovir inhibition of IDO to decrease Tregs as a glioblastoma treatment adjunct[J].Journal of Neuroinflammation,2010,7:44-47.
[86]
DELMASTRO M M,PIGANELLI J D.Oxidative stress and redox modulation potential in type 1 diabetes[J].Clinical and Developmental Immunology,2011,2011:593863. doi: 10.1155/2011/593863.
[87]
TSE H M,MILTON M J,SCHREINER S,et al.Hyporesponsiveness signal leads to antigen-specific cytokine and reactive oxygen species third disruption of innate-mediated proinflammatory[J].The Journal of Immunology,2007,178:908-917.
[88]
VAY D,RIGAMONTI C,VIDALI M,et al.Anti-phospholipid antibodies associated with alcoholic liver disease target oxidized phosphatidylserine on apoptotic cell plasma membranes[J].Journal of Hepatology,2006,44:183-189.
[89]
NINDL G,PETERSON N R,HUGHES E F,et al.Effect of hydrogen peroxide on proliferation,apoptosis and interleukin-2 production of Jurkat T cells[J].Biomedical Sciences Instrumentation,2004,40:123-128.
[90]
LARBI A,KEMPF J,PAWELEC G.Oxidative stress modulation and T cell activation[J].Experimental Gerontology,2007,42:852-858.
[91]
MEIER P,SPERTINI F,BLANC E,et al.Oxidized low-density lipoproteins activate CD4+ T cell apoptosis in patients with end stage renal disease through Fas engagement[J].Journal of the American Society of Nephrology,2007,18:331-342.
