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动物体内细胞色素酶P3A4与饲料黄曲霉毒素B1毒性的关系

DOI: 10.3969/j.issn.1006-267x.2013.01.003

Keywords: 细胞色素酶P3A4,黄曲霉毒素B1,抗氧化剂

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Abstract:

黄曲霉毒素B1(aflatoxinB1,AFB1)作为黄曲霉主要的代谢产物之一,进入动物体内后主要影响动物的抗氧化系统和免疫系统,是霉菌毒素中主要的致病致癌物质。AFB1代谢主要存在于动物肝脏中,肝微粒体中的细胞色素酶P450(cytochromeP450,CYP450s)是动物体内参与多种药物及毒物代谢的主要酶类。细胞色素酶P3A4(cytochromeP3A4,CYP3A4)是CYP450s的同工酶,主要参与肝脏内AFB1的代谢。进入动物机体内的AFB1经CYP3A4代谢的产物一部分与DNA、RNA结合产生致毒效应;另一部分在谷胱甘肽过氧化物酶(GSH-Px)、谷胱甘肽硫转移酶(GST)等作用下进入血液和尿液,发生解毒效应。在饲料中添加抗氧化剂对于缓解AFB1的毒性有良好效果。饲料中添加一些天然物质或化学成分可以适当抑制肝脏内CYP3A4的活性,对于研究AFB1对机体的损伤具有重要意义,还可为开发新的饲料添加剂提供新思路。

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