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蛋白质界面网络中模体和模块的探测

DOI: 10.11830/ISSN.1000-5013.2014.01.0061

Keywords: 蛋白质, 肽链网络, 界面网络, 模体, 模块, 拓扑性质

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Abstract:

基于复杂网络研究蛋白质界面网络中的模体和模块,发现蛋白质界面网络与蛋白质肽链网络的拓扑性质有差异.蛋白质界面网络中的模体类型和数量受截断距离R影响较大,R值不同,网络中的模体类型和数量都有较大差别.蛋白质界面网络中存在模块结构,分析R为0.5,0.7,1.2,2.4 nm时网络中存在的3-派系-模块,发现当R为0.7 nm时的蛋白质界面网络模块划分比较符合实际.最后,分析蛋白质界面网络中的模块与其拓扑性质的关系,发现界面网络中的节点数与3-派系-模块数呈线性关系.

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