全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...
同位素  2011 

碳酸酐酶Ⅸ在核医学中的研究进展

, PP. 140-145

Keywords: 碳酸酐酶Ⅸ,抑制剂,核医学,研究进展

Full-Text   Cite this paper   Add to My Lib

Abstract:

碳酸酐酶Ⅸ(CarbonicanhydraseⅨ,CAⅨ)是碳酸酐酶家族(Carbonicanhydrases,CAs)的异构体之一,在许多肿瘤中过量表达,是一种与肿瘤相关的跨膜糖蛋白。它催化CO2水解为碳酸氢根和氢离子,维持肿瘤细胞内的pH,酸化细胞外环境,有利于肿瘤的生长和转移。在核医学的靶向诊断和治疗中,CAⅨ成为一个抗肿瘤药物的靶向目标,也成为病人病情的一个预后因子。CAⅨ抑制剂可以作为一种诊断药物,用于肿瘤的分子影像;也可以作为一种治疗药物,阻断CAⅨ所调控的通路。利用89Zr、111In、124I或125I标记靶向CAⅨ的单克隆抗体或其片段进行分子影像,能精确定位CAⅨ的分布,灵敏检测CAⅨ的表达情况;利用90Y、131I、177Lu或186Re标记靶向CAⅨ的单克隆抗体,在放免疫治疗中可有效延迟肿瘤的生长。本文对CAⅨ及其在核医学中的研究进展进行了综述。

References

[1]  Pastorekova S, Zavadova Z, Kostal M, et al. A novel quasiviral agent, MaTu, is a two-component system[J]. Virology, 1992, 187(2): 620-626.
[2]  Pastorek J, Pastorekova S, Callebaut I, et al. Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonicanhydrase and a putative helix-loop-helix DNA-binding segment[J]. Oncogene, 1994, 9(10): 2 877-2 888.
[3]  KizakaKondoh S, Tanaka S, Harada H, et al. The HIF-1-active microenvironment: an environmental target for cancer therapy[J]. Advanced Drug Delivery Reviews, 2009, 61(7-8): 623-632.
[4]  Huang LE, Bindra RS, Glazer PM, et al. Hypoxia-induced genetic instability: a calculated mechanism underlying tumor progression [J]. Journal of Molecular Medicine-Jmm, 2007, 85(2): 139-148.
[5]  Woelber L, Kress K, Kersten JF, et al. Carbonic anhydrase Ⅸ in tumor tissue and sera of patients with primary cervical cancer[J]. Bmc Cancer, 2011, 11: 10.
[6]  Eriksen JG, Overgaard J. Lack of prognostic and predictive value of CA Ⅸ in radiotherapy of squamous cell carcinoma of the head and neck with known modifiable hypoxia: an evaluation of the DAHANCA 5 study[C]//10th International Wolfsberg Meeting on Molecular Radiation Biology/Oncology. Wolfsberg: AUSTRIA, 2007: 383-388.
[7]  Sherwood BT, Coquhoun AJ, Richardson D, et al. Carbonic anhydrase Ⅸ expression and outcome after radiotherapy for muscle-invasive bladder cancer [J]. Clinical Oncology, 2007, 19(10): 777-783.
[8]  Patard JJ, Fergelot P, Karakiewicz PI, et al. Low CAⅨ expression and absence of VHL gene mutation are associated with tumor aggressiveness and poor survival of clear cell renal cell carcinoma[J]. International Journal of Cancer, 2008, 123(2): 395-400.
[9]  Kim SJ, Shin HJ, Jung KY, et al. Prognostic value of carbonic anhydrase Ⅸ and Ki-67 expression in squamous cell carcinoma of the tongue[J]. Japanese Journal of Clinical Oncology, 2007, 37(11): 812-819.
[10]  Ilie M, Mazure NM, Hofman V, et al. High levels of carbonic anhydrase Ⅸ in tumour tissue and plasma are biomarkers of poor prognostic in patients with non-small cell lung cancer [J]. British Journal of Cancer, 2010, 102(11): 1 627-1 635.
[11]  Javela S, Parkkila S, Bragge H, et al. Carbonic anhydrase Ⅸ in oligodendroglial brain tumors [J]. Bmc Cancer, 2008, 8: 1.
[12]  Supuran CT. Development of small molecule carbonic anhydrase Ⅸ inhibitors. International Carbonic Anhydrase Ⅸ (CAⅨ) Symposium[M]. Brussels: BELGIUM, 2007: 39-40.
[13]  Casey JR, Morgan PE, Vullo D, et al. Carbonic anhydrase inhibitors: design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme Ⅸ [J]. Journal of Medicinal Chemistry, 2004, 47(9): 2 337-2 347.
[14]  Cecchi A, Hulikova A, Pastorek J, et al. Carbonic anhydrase inhibitors: design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase Ⅸ that inhibit isozyme Ⅸ-mediated acidification of hypoxic tumors [J]. Journal of Medicinal Chemistry, 2005, 48(15): 4 834-4 841.
[15]  Colinas PA, Bravo RD, Vullo D, et al. Carbonic anhydrase inhibitors: inhibition of cytosolic isoforms Ⅰ and Ⅱ, and extracellular isoforms Ⅳ, Ⅸ, and Ⅻ with sulfamides incorporating sugar moietie[J]. Bioorganic & Medicinal Chemistry Letters, 2007, 17(18): 5 086-5 090.
[16]  Thiry A, Supuran CT, Masereel B, et al. Recent developments of carbonic anhydrase inhibitors as potential anticancer drugs[J]. Journal of Medicinal Chemistry, 2008, 51(11): 3 051-3 056.
[17]  Lopez M, Paul B, Hofmann A, et al. S-glycosyl primary sulfonamidesn-a new structural class for selective inhibition of cancer-associated carbonic anhydrases[J]. Journal of Medicinal Chemistry, 2009, 52(20): 6 421-6 432.
[18]  Akurathi V, Dubois L, Lieuwes NG, et al. Synthesis and biological evaluation of a Tc-99m-labelled sulfonamide conjugate for in vivo visualization of carbonic anhydrase Ⅸ expression in tumor hypoxia[J]. Nuclear Medicine and Biology, 2010, 37(5): 557-564.
[19]  Vullo D, Scozzafava A, Pastorekova S, et al. Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme Ⅸ with fluorine-containing sulfonamides. The first subnanomolar CA Ⅸ inhibitor discovered[J]. Bioorganic & Medicinal Chemistry Letters, 2004, 14(9): 2 351-2 356
[20]  Zhang L, Cecic I, Cheng Z, et al. In Vitro evaluation of 18F-2,3,5,6-tetrafluoro-3’-sulfamoylbenzanilide as a potential PET probe for carbonic anhydrase Ⅸ[J]. Mol Imaging Biol, 2006, 8: 110. 
[21]  Schrama D, Reisfeld RA, Becker JC. Antibody targeted drugs as cancer therapeutics[J]. Nature Reviews Drug Discovery, 2006, 5(2): 147-159.
[22]  Chrastina A, Zavada J, Parkkila S, et al. Biodistribution and pharmacokinetics of I-125-labeled monoclonal antibody M75 specific for carbonic anhydrase Ⅸ, an intrinsic marker of hypoxia, in nude mice xenografted with human colorectal carcinoma[J]. International Journal of Cancer, 2003, 105(6): 873-881.
[23]  Steffens MG, Boerman OC, Oosterwijk Wakka JC, et al. Targeting of renal cell carcinoma with iodine-131-labeled chimeric monoclonal antibody G250[J]. Journal of Clinical Oncology, 1997, 15(4): 1 529-1 537.
[24]  Steffens MG, Boerman OC, de Mulder PHM, et al. Phase Ⅰ radioimmunotherapy of metastatic renal cell carcinoma with I-131-labeled chimeric monoclonal antibody G250 [J]. Clinical Cancer Research, 1999, 5(10): 3 268S-3 274S.
[25]  Brouwers AH, van Eerd JEM, Frielink C, et al. Optimization of radioimmunotherapy of renal cell carcinoma: labeling of monoclonal antibody cG250 with I-131, Y-90, Lu-177, or Re-186[J]. Journal of Nuclear Medicine, 2004, 45(2): 327-337.
[26]  Stillebroer AB, Oosterwijk E, Mulders PFA, et al. Radioimmunotherapy with lutetium-177 labeled monoclonal antibody cG250 in patients with advanced renal cell carcinoma[J]. Cancer Biotherapy and Radiopharmaceuticals, 2008, 23(4): 523-524.
[27]  Divgi CR, Pandit-Taskar N, Jungbluth AA, et al. Preoperative characterisation of clear-cell renal carcinoma using iodine-124-labelled antibody chimeric G250 (I-124-cG250) and PET in patients with renal masses: a phase Ⅰ trial [J]. Lancet Oncology, 2007, 8(4): 304-310.
[28]  Troost EGC, Bussink J, Kaanders J, et al. Comparison of different methods of CA Ⅸ quantification in relation to hypoxia in three human head and neck tumor lines[J]. Radiotherapy and Oncology, 2005, 76(2): 194-199.
[29]  Hoeben BAW, Kaanders J, Franssen GM, et al. PET of hypoxia with Zr-89-labeled cG250-F(ab’)(2) in head and neck tumors[J]. Journal of Nuclear Medicine, 2010, 51(7): 1 076-1 083.
[30]  Carlin S, Khan N, Ku T, et al. Molecular targeting of carbonic anhydrase Ⅸ in mice with hypoxic HT29 colorectal tumor xenografts[J]. Plos One, 2010, 5(5): e10 857.
[31]  武明星,郭飞虎,施玲丽,等. 一种磺胺类碳酸酐酶Ⅸ抑制剂的合成[J]. 精细化工,2008, 25(9):850-853.
[32]  武明星,郭飞虎,施玲丽,等. 一种含氟原子和三嗪环的磺胺类化合物的合成[J]. 精细化工,2008,25(10):945-947.
[33]  Juhasz M, Chen J, Lendeckel U, et al. Expression of carbonic anhydrase Ⅸ in human pancreatic cancer[J]. Alimentary Pharmacology & Therapeutics, 2003, 18(8): 837-846.
[34]  Hynninen P, Vaskivuo L, Saarnio J, et al. Expression of transmembrane carbonic anhydrases Ⅸ and Ⅻ in ovarian tumours[J]. Histopathology, 2006, 49(6): 594-602.
[35]  Svastova E, Hulikova A, Rafajova M, et al. Hypoxia activates the capacity of tumor-associated carbonic anhydrase Ⅸ to acidify extracellular pH [J]. Febs Letters, 2004, 577(3): 439-445.
[36]  Swietach P, Wigfield S, Supuran CT, et al. Cancer-associated, hypoxia-inducible carbonic anhydrase Ⅸ facilitates CO2 diffusion:International carbonic anhydrase Ⅸ (CA Ⅸ) Symposium[M]. Brussels: BELGIUM, 2007: 22-24.
[37]  Chiche J, Ilc K, Laferriere J, et al. Hypoxia-inducible carbonic anhydrase Ⅸ and Ⅻ promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH[J]. Cancer Research, 2009, 69(1): 358-368.
[38]  Svastova E, Zilka N, Zat’ovicova M, et al. Carbonic anhydrase Ⅸ reduces E-cadherin-mediated adhesion of MDCK cells via interaction with beta-catenin [J]. Experimental Cell Research, 2003, 290(2): 332-345.
[39]  Thiry A, Dogne JM, Masereel B, et al. Targeting tumor-associated carbonic anhydrase Ⅸ in cancer therapy [J]. Trends in Pharmacological Sciences, 2006, 27(11): 566-573.
[40]  de Simone G, Supuran CT. Carbonic anhydrase Ⅸ: Biochemical and crystallographic characterization of a novel antitumor target [J]. BBA-Proteins Proteomics, 2010, 1 804(2): 404-409.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133