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舌鳞癌β-DG缺失及意义探讨

, PP. 54-56

Keywords: ,鳞状细胞癌,β-肌营养不良蛋白聚糖,免疫组织化学

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Abstract:

目的研究舌鳞癌联结细胞与细胞外基质的关键结构β-DG的变异情况。方法免疫组化SP法,用NCL-b-DGBeta-Dystroglycan鼠单克隆抗体43DAG1/3D5,以正常舌黏膜为对照,研究正常β-DG所在部位,以及舌鳞癌中β-DG的变异特点。结果正常舌黏膜上皮β-DG主要位于其上皮的基底层,以基底膜处最为集中;舌鳞癌组织的癌巢周围及癌细胞膜处β-DG缺失。结论在舌鳞癌中,联接细胞骨架和细胞外基质的结构从β-DG处断裂。细胞内和细胞外联接的断裂,可能会使癌细胞生长的自限性丧失,从而导致癌细胞获得侵袭与转移的能力。

References

[1]  Winder SJ?The complexities of dystroglycan[J].Trends in Biochemi c Sci,2001,26(2):118-124??
[2]  Cross SS,Lippitt J,Mitchell A,et al?Expression of beta-dystroglycan i s redu ced or absent in many human carcinomas[J].Histopathology,2008,53(5):561- 566??
[3]  Silva P,Slevin NJ,Sloan P,et al?Prognostic significance of tumor hypo xia i nducible factor-1 alpha expression for outcome after radiotherapy in oropharyn geal cancer[J].Int J Radiat Oncol Biol Phys,2008,72(5):1551-1559??
[4]  〖JP2〗Garzino-Demo P,Dell'Acqua A,Dalmasso P,et al?〖JP〗Clinicopath ological parameters and outcome of 245 patients operated for oral squamous cell carcinoma[J].J Cranio-Maxillofac Surg,2006,34:344-350??
[5]  Woolgar JA?Histopathological prognosticators in oral and oropharyngeal s quamous cell carcinoma[J].Oral Oncol,2006,42:229-239??
[6]  Songra AK,Ng SY,Farthing P,et al?Observation of tumour thickness and resec tion margin at surgical excision of primary oral squamous cell carcinoma-assessm ent by ultrasound[J].Int J Oral Maxillofac Surg,2006,35:324-331??
[7]  Hood JD,Cheresh DA?Role of integrins in cell invasion and migration[J ].Nat Rev Cancer,2002(2):91-100??〖JP2〗
[8]  Russo K,Di Stasio E,Macchia G,et al?Characterization of the beta-dyst roglycan growth factor receptor 2(Grb2)interaction[J].Biochem Biophys Res Comm un,2000,274:93-98

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