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甘珀酸钠对小鼠急性肝损伤保护作用的研究

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Keywords: 甘珀酸钠,急性肝损伤,四氯化碳

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Abstract:

目的探讨甘珀酸钠(carbenoxolonesodium,CS)对四氯化碳(CCl?4)所致小鼠急性肝损伤的保护作用。方法昆明种小鼠60只随机分为6组,各组分别每天给予不同剂量(160、80、40mg?kg??-1?)的CS和联苯双酯滴丸(200mg?kg??-1?)灌胃,对照组和模型组给予生理盐水。7d后,除空白对照组外各组小鼠皮下注射0?1%CCl?4制备急性肝损伤模型,16h后取血检测血清ALT、AST活性;测定肝组织匀浆中MDA含量和SOD、GSH的活性及观察肝脏病理学变化。结果CS(160、80mg?kg??-1?)能降低CCl?4所致急性肝损伤小鼠血清ALT、AST活性(?P?<0?01),降低肝脏MDA的含量(?P?<0?01),增强GSH和SOD活力(?P?<0?01,?P?<0?05),并能明显改善肝组织的病理学损伤。结论CS对CCl?4所致小鼠急性肝损伤具有保护作用。

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