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乳腺肿块腋窝淋巴结超声造影与人乳腺珠蛋白基因检测对比研究

, PP. 435-438

Keywords: 乳腺肿块,超声造影,前哨淋巴结,人乳腺珠蛋白基因,逆转录聚合酶链反应

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Abstract:

目的通过分析乳腺肿块患者皮下注射超声造影剂(SonoVue)后腋窝淋巴结(ALN)的增强情况并检测前哨淋巴结(SLN)中人乳腺珠蛋白基因(hMAMmRNA)的表达,探讨超声造影与hMAMmRNA检测在诊断乳腺癌SLN的应用前景。方法21例乳腺肿块患者的肿物周围相同部位皮下先后分别注射造影剂和美蓝,观察同侧ALN的增强情况,术前对SLN标记,术后离体标本行病理及hMAMmRNA的逆转录-聚合酶链式反应(RT-PCR)检测。结果21例患者造影后15例检出SLN,检出率71.4%(15/21),美蓝染色后检出SLN19例,检出率90.5%(19/21),两组诊断准确率差异无统计学意义(P>0.05)。恶性者共检出SLN38个,病理显示15个转移,RT-PCR有26个阳性;良性患者11个SLN,且病理与RT-PCR均为阴性;两者检测的阳性率分别为75.5%(37/49)、97.9%(48/49),差异有统计学意义。结论皮下注射SonoVue超声造影可较好地检测出SLN并可判断其良恶性。

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