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氧化苦参碱对癫痫大鼠学习记忆功能的影响

, PP. 1269-1271

Keywords: 氧化苦参碱,癫痫,学习记忆,p-JNK

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Abstract:

目的观察氧化苦参碱(Oxymatrine,OXY)对青霉素(Penicillin,PEN)致痫大鼠学习记忆功能和海马区p-JNK表达的影响。方法成年SD大鼠随机分为生理盐水对照组、青霉素致痫(EP)组(800万U?kg?-1)、氧化苦参碱组(147.45mg?kg?-1)和苯巴比妥钠(10mg?kg?-1)阳性对照组,腹腔注射青霉素诱导大鼠癫痫发作,观察大鼠行为学改变,Morris水迷宫检测大鼠空间学习和记忆,免疫组化检测大鼠海马区p-JNK阳性细胞数。结果与EP组相比,OXY组大鼠空间记忆能力明显改善;海马组织内p-JNK阳性细胞数明显降低。结论OXY可以对癫痫大鼠在空间学习和记忆方面起到保护作用。

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