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Twist、E-cadherin和HGF在胃癌组织中的表达及意义

, PP. 1253-1256

Keywords: 胃癌,Twist,上皮钙黏蛋白,肝细胞生长因子

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Abstract:

目的探讨Twist、上皮钙黏蛋白(E-cadherin)和肝细胞生长因子(HGF)与胃癌发生发展的关系及三种蛋白之间的关系。方法采用免疫组织化学法检测60例胃癌组织及对应癌旁组织中Twist、E-cadherin和HGF的表达,将结果与临床资料进行统计分析。结果Twist、E-cadherin和HGF在胃癌组织中的表达与癌旁组织比较,差异均具有统计学意义(P<0.01);Twist、E-cadherin表达均与肿瘤TNM分期、分化程度、淋巴结转移及浸润深度相关(P<0.05);HGF高表达与胃癌TNM分期、分化程度、淋巴结转移相关(P<0.05);Twist表达与E-cadherin表达呈负相关(P=0.011)、与HGF表达呈正相关(P=0.005)。结论在胃癌组织中,Twist和HGF高表达,E-cadherin低表达,提示此三种蛋白可能与胃癌的发生发展有密切关系。

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