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趋化因子受体CXCR7在人肝癌细胞株中的表达及意义

, PP. 588-591

Keywords: 趋化因子受体,CXCR7,肝细胞肝癌

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Abstract:

目的探讨趋化因子受体(Chemokinereceptor,CXCR7)在不同肝癌细胞株中的相对表达强度及意义。方法采用RT-PCR、Westernblot法,检测8株不同转移潜能肝癌细胞中趋化因子受体CXCR7在mRNA及蛋白水平的表达情况。结果CXCR7在8株肝癌细胞中的表达水平差异存在统计学意义,无论是mRNA水平还是蛋白水平,高转移潜能肝癌细胞株(MHCC97-L、MHCC97-H、HCCLM3)CXCR7的表达明显高于普通转移潜能肝癌细胞株(HepG2、PLC/PRF/5、SMMC-7721、BEL-7402、Hep3B),P<0.01。结论CXCR7与肝癌的发生、发展及预后有一定的相关性。

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