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左西孟旦治疗老年顽固性心力衰竭的短期疗效观察

, PP. 912-915

Keywords: 左西孟旦,心力衰竭,脑利钠肽前体,QRS波时限,左室射血分数

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Abstract:

目的观察左西孟旦对65岁以上老年顽固性心衰患者脑利钠肽前体(BNP)、QRS波时限和左室射血分数(LVEF)的影响。方法选择2008年1月至2010年12月我科收治的142例慢性心力衰竭失代偿期的患者,经强心、利尿、扩血管治疗后仍有胸闷、气短或夜间阵发性呼吸困难或端坐呼吸。纳入患者随机分为未使用左西孟旦组(D组)、使用左西孟旦24h组(A组)、48h组(B组)和72h组(C组),比较四组用药前、后24h、48h、72hBNP、QRS波时限以及LVEF用药前、后72h的变化。结果用药前和用药24h后,各组BNP水平差异无统计学意义(P>0.05),用药24h后与同组基线比较BNP水平差异亦无统计学意义(P>0.05);用药48h和72h后,各组BNP水平差异无统计学意义(P0.05);用药72h后,B组和C组QRS波时限均显著低于同组基线、用药24h和48h后,且低于其他两组用药后72h(P均0.05);用药72h后,B组和C组LVEF均显著高于同组基线,且高于其他两组用药后72h(P均<0.05)。结论延长左西孟旦给药时间能够有效改善老年顽固性心衰患者的短期心脏功能。

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