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幽门螺杆菌oipA基因与慢性萎缩性胃炎及胃癌胃黏膜组织中 FAK表达的关系研究

Keywords: 黏着斑激酶,幽门螺杆菌,前炎症蛋白,慢性萎缩性胃炎,胃癌

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Abstract:

目的探讨幽门螺杆菌(Helicobacterpylori,HP)oipA基因与萎缩性胃炎及胃癌患者胃黏膜组织中FAK表达的关系及意义。方法收集慢性萎缩性胃炎及胃癌患者胃黏膜活检标本130例,应用PCR法检测HP阳性标本中oipA基因,免疫组化SP法检测胃黏膜组织中FAK的表达水平。结果在两组患者HP阳性标本中,oipA基因阳性率为66.3%(59/89),其中慢性萎缩性胃炎标本oipA检出率56.5%(26/46);胃癌标本oipA基因检出率为76%(33/43),两者差异有统计学意义。慢性萎缩性胃炎组及胃癌组中HP阴性、HP阳性oipA阴性、HP阳性oipA阳性三种情况FAK的表达均依次增高,三者差异均有统计学意义(慢性萎缩性胃炎组χ2=6.703,P<0.05;胃癌组χ2=4.416,P<0.05)。oipA阳性的胃癌标本中FAK表达比慢性萎缩性胃炎中高(P<0.05)。结论HPoipA可能上调萎缩性胃炎及胃癌患者胃黏膜组织中FAK的表达。

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