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华西医学  2015 

炎症性肠病患者术前应用英夫利昔与术后发生感染性并发症风险的Meta分析

DOI: 10.7507/1002-0179.20150082, PP. 270-274

Keywords: 英夫利昔,炎症性肠病,术后感染性并发症,Meta分析,观察性研究

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Abstract:

目的?系统评价炎症性肠病患者术前应用英夫利昔(IFX)是否提高术后发生感染性并发症的风险。方法?计算机检索PubMed、WebofScience、中国生物医学文献数据库、中国期刊全文数据库和万方数据库,检索时间均为1990年1月-2013年4月,搜集研究炎症性肠病患者术前应用IFX是否提高术后发生感染性并发症的风险的研究,由2位研究者按照纳入与排除标准独立筛选文献、提取资料和评价质量后,结果应用RevMan5.1软件进行Meta分析。结果?最终纳入14项队列研究。Meta分析结果显示溃疡性结肠炎患者中IFX组和对照组术后发生感染性并发症风险差异无统计学意义RR=0.99,95%CI(0.47,2.07),P=0.97,克罗恩病患者中IFX组和对照组术后发生感染性并发症风险差异无统计学意义RR=1.32,95%CI(0.87,1.98),P=0.19。结论?有限数据的Meta分析结果显示,术前应用IFX并不增加术后感染性并发症的风险。

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