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华西医学  2012 

降钙素原与创伤的研究进展

, PP. 789-793

Keywords: 降钙素原,创伤,感染,脓毒症

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Abstract:

创伤是导致炎症反应的重要因素之一,炎症反应和感染是创伤后常见的病理生理过程,而由此所致的脓毒症或脓毒症休克是创伤后患者死亡的重要原因。感染的早期诊治与预后密切相关。临床上许多感染监测指标如体温、C反应蛋白、白细胞计数、白细胞介素6和肿瘤坏死因子α等诊断感染缺乏特异性,而血培养阳性率低、耗时长且较难区分细菌定植或感染,在临床应用受到很大的限制,使得临床医师对于创伤后感染的诊断更加困难。近年来降钙素原(PCT)是被认为是诊断细菌感染有效的生物学指标。诸多研究认为PCT可以作为诊断创伤后并发症的工具,其水平的高低与创伤的严重程度及预后相关。现就PCT与创伤的研究进展进行综述。

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