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华西医学  2013 

糖类抗原125与慢性阻塞性肺疾病急性加重期及右心功能关系的研究

DOI: 10.7507/1002-0179.20130129, PP. 411-412

Keywords: 慢性阻塞性肺疾病,急性加重期,右心功能,糖类抗原125

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Abstract:

目的 探讨糖类抗原125(CA125)与慢性阻塞性肺疾病急性加重期(AECOPD)、右心功能临床状态关系。方法 收集2011年3月-2012年2月住院AECOPD患者54例,根据患者临床症状及心脏超声结果将其分为3组,每组各18例。A组为单纯AECOPD,B组为AECOPD伴右心功能代偿期,C组为AECOPD伴右心功能失代偿期;另有年龄匹配的同期入院的无明显器质性病变患者18例作为对照组(D组)。入院后搜集各组患者临床基本资料,测量CA125值。结果 A、B、C、D组CA125水平分别为(25.40±12.48)、(10.22±3.42)、(39.82±25.70)、(91.91±39.98)U/mL。与D组比较,A、B、C组的CA125水平均明显升高(P≤0.001);C组与其他组比较,CA125水平升高(P=0.000);A、B组CA125水平差异无统计学意义(P=0.168)。结论 升高的CA125与AECOPD临床状态及其恶化有一定相关性,可能是监测慢性肺源性心脏病心功能失代偿期的有用指标。

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