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白细胞介素-17A在AR患者鼻粘膜中的表达及意义

, PP. 141-144

Keywords: 变应性鼻炎,白细胞介素-17A,炎症,嗜酸性粒细胞

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Abstract:

目的观察白细胞介素-17A(IL-17A)在变应性鼻炎(AR)患者鼻粘膜中的表达,探讨其意义。方法2013年6月~2014年6月,收集AR患者40例(AR组)和非AR患者25例(对照组),对其临床症状进行评分,测定每个受试者的血清免疫球蛋白E(IgE)和嗜酸性粒细胞含量;取鼻粘膜组织,用免疫组织化学技术(IHC)检测IL-17A的表达,ELI?SA检测IL-17A的含量,分析鼻粘膜组织IL-17A的表达量与患者临床症状评分、血清中IgE含量及血液中酸性粒细胞含量的相关性。结果IL-17A主要在浸润的炎性细胞中表达,组织中IL-17A的表达量与AR的症状评分呈正相关(R2=0.815,P=0.001),与血清中IgE含量不相关(R2=0.06,P=0.11),与血液中嗜酸性粒细胞含量不相关(R2=0.11,P=0.06)。结论在鼻腔黏膜上IL-17A的表达与变应性鼻炎的严重程度相关。

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