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儿童异基因造血干细胞移植后早期真菌感染的临床观察

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Keywords: 儿童,异基因造血干细胞移植,真菌感染,伊曲康唑,预防

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Abstract:

目的探讨儿童异基因造血干细胞移植(Allo-HSCT)后使用伊曲康唑注射液预防早期真菌感染的疗效,并评价血浆真菌(1-3)-β-D-葡聚糖检测(G试验)的临床诊断价值。方法回顾性调查分析2008年3月~2011年2月南方医院儿科145例异基因造血干细胞移植术后早期真菌感染的发生情况。结果伊曲康唑注射液预防组及口服抗真菌药预防组的早期真菌感染率分别为5.50%和22.22%,两组早期死亡率分别为1.83%和11.11%,差异均有统计学意义(P结果阳性,其中3例为真菌感染病例;39例患儿结果阴性,其中1例为真菌感染病例;G试验对诊断真菌感染无统计学意义(P>0.05)。结论伊曲康唑注射液能有效、安全地预防儿童allo-HSCT术后早期真菌感染。G试验在儿童allo-HSCT术后早期合并真菌感染诊断方面的应用价值有待进一步探讨。

References

[1]  张之南.血液病诊断及疗效标准[M].第3版.北京:科学技术出版社,2007.
[2]  中国侵袭性真菌感染工作组.血液病/恶性肿瘤患者侵袭性真菌感染的诊断标准与治疗原则(第三次修订版)[J].中华内科杂志,2010,49:451-454.
[3]  Sinkó J, Csomor J, Nikolova R, et al. Invasive fungal disease in allogeneic hematopoietic stem cell transplant recipients: an autopsy-driven survey[J]. Transpl Infect Dis. 2008, 10(2):106-109.
[4]  Gratwohl A,Brand R,Frassoni F,et a1.Cause of death after allogeneic haematopoietic stem cell transplantation (HSCT) in early leukaemias:all EBMT analysis of lethal infectious complications and changes over calendar time.Bone Marrow Transplant,2005,36:757-769.
[5]  Freifeld AG, Bow EJ, Sepkowitz KA, et al. Clinical practice guildeline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 Update by the Infectious Diseases Society of America. Clin Infect Dis, 2011, 52: 427-431.
[6]  纪宇,许兰平,黄晓军. 血液肿瘤患者抗真菌经验治疗与抢先治疗首选药物的现状调查研究[J]. 中华血液学杂志, 2013, 34(6):473-477.
[7]  Odabasi Z,Mattiuzzi G,Estey E,et a1.Beta-D-glucan as a diagnostic adjunct for invasive funsal infections:validation,cutof development.and performance in patients with acute myelngenous leukemia and myelodysplastic syndrome[J].Clin Infect Dis,2004,39:199-205.
[8]  Yoshida M,Roth RJ,Grunfeld C,et al,Soluble(1-3)-beta-D-gluean purified from Candida albieans:biological effect and distribution in blood and organs in rabbits[J]. J Lab Clin Med,1996,128(1):102-114.
[9]  陈宇清,高 蕾,朱小敏,等.血浆(1,3)-β-D-葡聚糖抗原检测对器官移植术后患儿侵袭性肺部真菌感染的诊断价值[J]. 实用临床医药杂志,2009,13(3):2-6.
[10]  Pazos C,Ponton J,Del Palocio A.Contribution of(1,3)- β-D-glucan chromogenic assay to diagnosis and therapeutic monitoring of invasive aspergillosis in neurpenic adult patients:a comparison with serial screening for circulating galactomannan[J].J Clin Microbiol,2005,43(1):299-305.

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