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ABCB1C3435T基因多态性与人群缺血性卒中的相关性

DOI: 10.13604/j.cnki.46-1064/r.2015.09.28, PP. 1127-1129

Keywords: 多耐药基因1,单核苷酸多态性,缺血性卒中

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Abstract:

目的研究多耐药基因1(ABCB1)基因多态性与人群缺血性卒中发生的相关性。方法采用病例对照研究方法,对120例缺血性卒中患者和110例健康对照者,应用Taqman探针和直接测序的方法检测血浆中ABCB1C3435T基因多态性,了解其基因多态性分布情况。结果ABCB1C3435T基因型在病例组CC、CT和TT的分布频率分别为50%、25%和25%,在对照组中分别为72.7%、15.5%和11.8%,差异均有统计学意义(POR=2.35,95%CI1.19~4.46;OR=3.08,95%CI1.48~6.40)。结论ABCB1C3435T基因型分布存在种族差异,ABCB1C3435T基因多态性与中国北方人群缺血性卒中发生相关。

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