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非小细胞肺癌组织中Kiss-1和VEGF与微血管密度的相关性

, PP. 1135-1137

Keywords: 非小细胞肺癌(NSCLC),Kiss-1蛋白,VEGF蛋白,免疫组织化学,微血管密度

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Abstract:

目的探讨肿瘤转移抑制基因蛋白(Kiss-1)和血管内皮生长因子(VEGF)在非小细胞肺癌(non-smallcelllungcancer,NSCLC)中的表达与微血管密度(MVD)相关性研究。方法收集我院NSCLC组织标本68例,采用免疫组化SP法检测各组Kiss-1和VEGF的表达和微血管密度(MVD)(CD34标记)。结果NSCLC组中Kiss-1和VEGF阳性率和MVD值均与对照组有明显差异(PPPP结论Kiss-1和VEGF在NSCLC发生和转移中可能起重要作用,Kiss-1和VEGF与NSCLC的浸润转移密切相关,可作为预后的判断指标。

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