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PCDGF、CD44v6、ICAM-1在结肠癌的表达及意义

, PP. 843-845

Keywords: 结肠癌,畸胎瘤细胞源性生长因子,CD44v6,细胞间黏附分子-1,免疫组化

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Abstract:

目的探讨畸胎瘤细胞源性生长因子(PCcell-derivedgrowthfactor,PCDGF)、CD44v6、细胞间黏附分子-1(Intercellularadhesionmolecule-1,ICAM-1)在结肠癌中的表达水平及其临床意义。方法应用免疫组化法检测40例结肠癌组织和40例癌旁非癌组织中PCDGF、CD44v6、ICAM-1的表达水平,并进行综合分析。结果癌组织PCDGF、CD44v6、ICAM-1表达率分别为62.5%(25/40)、52.5%(21/40)和62.5%(25/40),明显高于癌旁组织中的5.0%(2/40)、7.5%(3/40)和5.0%(2/40),差异有统计学意义(χ2=-27.1,17.2,27.1,P均结论结肠癌中PCDGF、CD44v6、ICAM-1的表达水平明显升高,三者参与了结肠癌的发生及转移过程。

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