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DC-CIK联合埃克替尼一线治疗晚期NSCLC的疗效分析

, PP. 1117-1119

Keywords: 肿瘤生物免疫治疗,分子靶向药物,埃克替尼,非小细胞肺癌,病例分析

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Abstract:

目的DC-CIK(DC细胞即树突状细胞,CIK细胞即细胞因子诱导的杀伤细胞)联合埃克替尼一线治疗晚期非小细胞肺癌(NSCLC)患者的早期临床疗效评估。方法18名晚期NSCLC患者接受DC-CIK联合埃克替尼治疗,埃克替尼为每日3次口服,每次125mg,疗程为3个月,在服用埃克替尼治疗过程中接受DC-CIK生物免疫治疗1~2个疗程。若出现不能耐受的不良反应或疾病进展时停用。结果其中疾病控制率为77.7%(14例),客观有效率为33.3%(6例),所有患者KPS评分均较治疗前有所升高,临床症状均得到不同程度缓解,部分患者外周血肿瘤标记物水平下降显著。共6例出现I度药物相关不良反应,为皮疹、腹泻和恶心。结论DC-CIK联合埃克替尼在一线治疗晚期NSCLC患者中早期临床效果显著,且不良反应轻微。

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