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STK15、P53蛋白在结肠癌中的表达及其临床意义

, PP. 104-106

Keywords: 丝氨酸/苏氨酸激酶15,P53蛋白,结肠癌,免疫组化,中心体

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Abstract:

目的探讨结肠癌组织中丝氨酸/苏氨酸激酶15(Serine/threoninekinase15,STK15)、P53蛋白的表达及其临床意义。方法采用免疫组织化学法检测72例结肠癌组织和36例癌旁正常组织中STK15、P53蛋白的表达情况,分析两者在结肠癌发生发展中相关性,及与结肠癌患者临床病理特征之间的关系。结果STK15、P53蛋白在结肠癌组织中的阳性表达率分别为65.3%(47/72)、69.4%(50/72),明显高于癌旁正常组织中的表达,两者在结肠癌的发生发展中比较差异有统计学意义(r=0.615,PPP>0.05)。结论STK15、P53在结肠癌中高表达,且两者在结肠癌中呈正相关,提示STK15、P53可能共同参与了结肠癌发生发展的过程,二者的表达可能与结肠癌的不良预后有密切关系。

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