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环境化学  2015 

四溴双酚-A和五溴酚对红鲫甲状腺组织结构的影响

Keywords: 甲状腺干扰物,四溴双酚-A,五溴酚,红鲫

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Abstract:

将红鲫(Carassiusauratus)分别暴露于0.25mg.l-1四溴双酚A(TBBPA)和0.05mg.l-1五溴酚(PBP)中6周,采用组织切片的方法,观测红鲫甲状腺滤泡形态结构的变化,并以100mg.l-1高氯酸钠(NaClO4)和0.25mg.l-1氯化镉(CdCl2)作为参照,探讨TBBPA和PBP在体时(invivo)对鱼类甲状腺可能的致毒机理.结果显示,经TBBPA和PBP暴露后,红鲫甲状腺发生了滤泡上皮增厚、细胞肥大和增生等现象,表明这两种溴化阻燃剂均能造成甲状腺结构的损伤.这与NaClO4所引起的甲状腺滤泡的变化非常相似,而与CdCl2所引起的滤泡上皮变薄刚好相反.由此推测,TBBPA和PBP在鱼体内可能引起甲状腺素水平的降低,进而导致甲状腺滤泡细胞的代偿性增生和肥大.

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