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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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基于气-液剪切作用制备壳聚糖季铵盐/海藻酸钠/CaCO3复合微胶囊及其性能研究
DOI: 10.11777/j.issn1000-3304.2015.15081, PP. 1336-1343
Keywords: 微胶囊,气-液剪切,天然高分子,CaCO3微粒,溶胀行为,药物释放
Abstract:
以天然高分子壳聚糖季铵盐和海藻酸钠为壁材,利用气-液剪切原理,在自制的微通道装置中通过复凝聚法形成壳聚糖季铵盐/海藻酸钠微胶囊;同时,原位沉淀法得到的CaCO3微粒被引入到微胶囊的囊壁中,最终得到壳聚糖季铵盐/海藻酸钠/CaCO3复合微胶囊.通过三维显微镜和扫描电镜观察复合微胶囊形态和尺寸,并统计复合微胶囊的平均粒径,探索制备复合微胶囊的最佳工艺条件.研究复合微胶囊在不同pH条件下、不同离子强度溶液中的溶胀行为.以水杨酸钠为模型药物,探讨复合微胶囊对药物的包埋作用和释放性能.
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