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化学进展  2015 

人体呼出气分析的技术进展及其在非侵入式医学诊断方面的临床应用前景

DOI: 10.7536/PC141021, PP. 321-335

Keywords: 呼出气分析,生物标识物,无创性,疾病诊断,挥发性有机化合物

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Abstract:

人体呼出气被视为血液顶空气体,通过肺泡交换排出体外,可在一定程度上反映人体的内源代谢情况。近些年,随着医学诊断无损化的不断发展,呼出气分析由于其无创性,无痛性,便捷性,具有临床疾病早期诊断与大规模筛查的潜力,受到越来越多的关注。研究表明,呼出气中包含的挥发性有机化合物和人体的疾病代谢状态密切相关,如丙酮与糖尿病,醛类物质与乳腺癌,烷烃类与氧化应激水平等。现代分析方法(如气相色谱、质谱、光谱、传感器等)对呼出气中上千种痕量组分的定性定量分析,使得呼出气分析成为可能。此文总结了呼出气分析的技术发展样品采集手段,预富集技术和定性定量分析技术。评价了呼出气生物标识物在糖尿病,乳腺癌,以及肺癌等疾病中的临床诊断前景。最后讨论了呼出气分析的技术在国内的发展现状及其面临的主要问题。

References

[1]  Di Francesco F, Fuoco R, Trivella M G, Ceccarini A. Microchem. J., 2005, 79: 405.
[2]  Buszewski B, Kesy M, Ligor T, Amann A. Biomed. Chromatogr., 2007, 21: 553.
[3]  Phillips M, Herrera J, Krishnan S, Zain M, Greenberg J, Cataneo R N. J. Chromatogr. B Biomed. Sci. Appl., 1999, 729: 75.
[4]  Novak B J, Blake D R, Meinardi S, Rowland F S, Pontello A, Cooper D M, Galassetti P R. Proc. Natl. Acad. Sci. U.S.A., 2007, 104: 15613.
[5]  Miekisch W, Schubert J K, Noeldge Schomburg G F. Clin. Chim. Acta, 2004, 347: 25.
[6]  Cao W, Duan Y. Clin. Chem., 2006, 52: 800.
[7]  Amann A, Costello B D, Miekisch W, Schubert J, Buszewski B, Pleil J, Ratcliffe N, Risby T. J. Breath Res., 2014, 8: 034001.
[8]  Shaji J, Jadhav D. RJPBCS, 2010, 1: 653.
[9]  Mukhopadhyay R. Anal. Chem., 2004, 76: 273A.
[10]  M. P. Scientific American, 1992, 267:74.
[11]  Hakim M, Broza Y Y, Barash O, Peled N, Phillips M, Amann A, Haick H. Chem. Rev., 2012, 112: 5949.
[12]  Anderson J C, Babb A L, Hlastala M P. Ann. Biomed. Eng., 2003, 31: 1402.
[13]  Galassetti P R, Novak B, Nemet D, Rose-Gottron C, Cooper D M, Meinardi S, Newcomb R, Zaldivar F, Blake D R. Diabetes Technol. Ther., 2005, 7: 115.
[14]  Lee J, Ngo J, Blake D, Meinardi S, Pontello A M, Newcomb R, Galassetti P R. J. Appl. Physiol., 2009, 107: 155.
[15]  Minh T D, Oliver S R, Ngo J, Flores R, Midyett J, Meinardi S, Carlson M K, Rowland F S, Blake D R, Galassetti P R. Am. J. Physiol. Endocrinol. Metab., 2011, 300: E1166.
[16]  Deng C, Zhang J, Yu X, Zhang W, Zhang X. J. Chromatogr. B Anal. Technol. Biomed. Life Sci., 2004, 810: 269.
[17]  Abbott S M, Elder J B, Spanel P, Smith D. Int. J. Mass Spectrom, 2003, 228: 655.
[18]  Schubert J K, Spittler K H, Braun G, Geiger K, Guttmann J. J. Appl. Physiol., 2001, 90: 486.
[19]  Pleil J D, Lindstrom A B. J. Chromatogr. B, 1995, 665: 271.
[20]  Miekisch W, Schubert J. TrAC, 2006, 25: 665.
[21]  Wilson H K, Monster A C. Occup. Environ. Med., 1999, 56: 753.
[22]  Li J, Peng Y, Liu Y, Li W, Jin Y, Tang Z, Duan Y. Clin. Chim. Acta, 2014, 436: 59.
[23]  Phillips M. Anal. Biochem., 1997, 247: 272.
[24]  De Prins S, Dons E, Van Poppel M, Int Panis L, Van de Mieroop E, Nelen V, Cox B, Nawrot TS, Teughels C, Schoeters G, Koppen G. Environ. Int., 2014, 73: 440.
[25]  Pennazza G, Santonico M, Incalzi R A, Scarlata S, Chiurco D, Vernile C, D’Amico A. Sensor Actuat. B-Chem., 2014, 204: 578.
[26]  Cao W, Duan Y. Critical Reviews Anal. Chem., 2007, 37: 3.
[27]  Vaira D, Holton J, Ricci C, Basset C, Gatta L, Perna F, Tampieri A, Miglioli M. Aliment. Pharmacol. Ther., 2002, 16: 105.
[28]  Amann A, Poupart G, Telser S, Ledochowski M, Schmid A, Mechtcheriakov S. Int. J. Mass Spectrom., 2004, 239: 227.
[29]  Lindinger C, Pollien P, Ali S, Yeretzian C, Blank I, Mark T. Anal. Chem., 2005, 77: 4117.
[30]  Moser B, Bodrogi F, Eibl G, Lechner M, Rieder J, Lirk P. Respir. Physiol. Neurobiol., 2005, 145: 295.
[31]  Harrison G R, Critchley A D J, Mayhew C A, Thompson J M. Br. J. Anaesth., 2003, 91: 797.
[32]  Lirk P, Bodrogi F, Raifer H, Greiner K, Ulmer H, Rieder J. Nephrol. Dial. Transplant., 2003, 18: 937.
[33]  Boschetti A, Biasioli F, van Opbergen M, Warneke C, Jordan A, Holzinger R, Prazeller P, Karl T, Hansel A, Lindinger W, Iannotta S. Postharvest. Biol. Tec., 1999, 17: 143.
[34]  Li F, Xie Z, Schmidt H, Sielemann S, Baumbach J I. Spectrochim. Acta. Part B At. Spectrosc., 2002, 57: 1563.
[35]  Ruzsanyi V, Baumbach J I, Sielemann S, Litterst P, Westhoff M, Freitag L. J. Chromatogr. A, 2005, 1084: 145.
[36]  Westhoff M, Litterst P, Freitag L, Urfer W, Bader S, Baumbach J I. Thorax, 2009, 64: 744.
[37]  Sigrist M, Bartlome R, Marinov D, Rey J, Vogler D, W?chter H. Appl. Phys. B, 2008, 90: 289.
[38]  McCurdy M R, Bakhirkin Y, Wysocki G, Lewicki R, Tittel F K. J. Breath. Res., 2007, 1: 014001.
[39]  Wang C, Sahay P. Sensors (Basel), 2009, 9: 8230.
[40]  Wang C, Mbi A, Shepherd M. IEEE Sens. J., 2010, 10: 54.
[41]  Righettoni M, Schmid A, Amann A, Pratsinis S E. J. Breath. Res., 2013, 7: 037110.
[42]  Schaller E, Bosset J O, Escher F. LWT-Food Sci. Technol., 1998, 31: 305.
[43]  Tisch U, Haick H. J. Breath. Res., 2014, 8: 027103.
[44]  Di Natale C, Macagnano A, Martinelli E, Paolesse R, D’Arcangelo G, Roscioni C, Finazzi-Agro A, D’Amico A. Biosens. Bioelectron., 2003, 18: 1209.
[45]  Huang H, Zhou J, Chen S, Zeng L, Huang Y. Sensor. Actuat. B-Chem., 2004, 101: 316.
[46]  Laffel L. Diabetes Metab. Res. Rev., 1999, 15: 412.
[47]  Musa-Veloso K, Likhodii S S, Cunnane S C. Am. J. Clin. Nutr., 2002, 76: 65.
[48]  Spanel P, Dryahina K, Rejskova A, Chippendale T W, Smith D. Physiol. Meas., 2011, 32: N23.
[49]  Kalapos M P. Biochim. et Biophys. Acta, 2003, 1621: 122.
[50]  Keller U, Lustenberger M, Stauffacher W. Diabetologia., 1988, 31: 24.
[51]  Aschmann S M, Long W D, Atkinson R. J. Phys. Chem. A, 2005, 110: 6617.
[52]  Salerno-Kennedy R, Cashman K D. Wien. Klin. Wochenschr., 2005, 117: 180.
[53]  Martínez-Lozano P, Zingaro L, Finiguerra A, Cristoni S. J. Breath. Res., 2011, 5: 016002.
[54]  Jones A E, Summers R L. J. Emerg. Med., 2000, 19: 165.
[55]  Owen O E, Trapp V E, Skutches C L, Mozzoli M A, Hoeldtke R D, Boden G, Reichard G. Diabetes, 1982, 31: 242.
[56]  Turner C, Parekh B, Walton C, Spanel P, Smith D, Evans M. Rapid Commun. Mass Spectrom., 2008, 22: 526.
[57]  Turner C, Spanel P, Smith D. Physiol. Meas., 2006, 27: 321.
[58]  Teshima N, Li J Z, Toda K, Dasgupta P K. Anal. Chim. Acta, 2005, 535: 189.
[59]  Schwarz K, Pizzini A, Arendacka B, Zerlauth K, Filipiak W, Schmid A, Dzien A, Neuner S, Lechleitner M, Scholl-Burgi S, Miekisch W, Schubert J, Unterkofler K, Witkovsky V, Gastl G, Amann A. J. Breath. Res., 2009, 3: 027003.
[60]  Spanel P, Dryahina K, Smith D. J. Breath. Res., 2007, 1: 011001.
[61]  Spanel P, Dryahina K, Smith D. J. Breath. Res., 2007, 1: 026001.
[62]  Smith D, Spanel P, Davies S. J. Appl. Physiol., 1999, 87: 1584.
[63]  Bloor R N, Spanel P, Smith D. Addict. Biol., 2006, 11: 163.
[64]  Musa-Veloso K, Rarama E, Comeau F, Curtis R, Cunnane S. Pediatr. Res., 2002, 52: 443.
[65]  Musa-Veloso K, Likhodii S S, Rarama E, Benoit S, Liu Y M, Chartrand D, Curtis R, Carmant L, Lortie A, Comeau F J, Cunnane S C. Nutrition, 2006, 22: 1.
[66]  Lawson L D, Wang Z J. J. Agric. Food Chem., 2005, 53: 1974.
[67]  Ghimenti S, Tabucchi S, Lomonaco T, Di Francesco F, Fuoco R, Onor M, Lenzi S, Trivella M G. J. Breath. Res., 2013, 7: 017115.
[68]  Guo D, Zhang D, Zhang L, Lu G. Sensor. Actuat. B-Chem., 2012, 173: 106.
[69]  Greiter M B, Keck L, Siegmund T, Hoeschen C, Oeh U, Paretzke H G. Diabetes Technol. Ther., 2010, 12: 455.
[70]  Yan Y, Wang Q, Li W, Zhao Z, Yuan X, Huang Y, Duan Y. RSC Adv., 2014, 4: 25430.
[71]  Siegel R, Naishadham D, Jemal A. CA Cancer J. Clin., 2013, 63: 11.
[72]  Hamid Q, Springall D R, Riveros-Moreno V, Chanez P, Howarth P, Redington A, Bousquet J, Godard P, Holgate S, Polak J M. Lancet, 1993, 342: 1510.
[73]  Saleh D, Ernst P, Lim S, Barnes P J, Giaid A. Faseb. J., 1998, 12: 929.
[74]  Abba A A. Ann. Thorac. Med., 2009, 4: 173.
[75]  Dupont L, Demedts M, Verleden G. Chin. J. Respir. Crit. Care. Med., 1999, A861.
[76]  Ekroos H, Tuominen J, Sovijarvi A R. Clin. Physiol., 2000, 20: 434.
[77]  Dupont L J, Demedts M G, Verleden G M. Chest, 2003, 123: 751.
[78]  任旭斌(Ren X B), 刘春涛(Liu C T), 黄玉芳(Huang Y F), 朱涛(Zhu T). 中国呼吸与危重监护杂志(Chin. J. Respir. Crit. Care. Med.), 2009, 8: 322.
[79]  柴静 (Chai J), 蒋萍 (Jiang P), 钱雪娇 (Qian X J). 山东大学学报(Journal of Shandong University), 2010, 48: 81.
[80]  尤玲燕(You L Y), 单霞(Shan X), 黄茂(Huang M). 江苏医药(Jiangsu Med.), 2011, 37: 1557.
[81]  Rosias P P, Dompeling E, Dentener M A, Pennings H J, Hendriks H J, Van Iersel M P, Jobsis Q. Pediatr. Pulmonol., 2004, 38: 107.
[82]  Kharitonov S A. Swiss Med. Wkly, 2004, 134: 175.
[83]  Clini E, Bianchi L, Pagani M, Ambrosino N. Thorax, 1998, 53: 881.
[84]  Fisher A J, Gabbay E, Small T, Doig S, Dark J H, Corris P A. Thorax, 1998, 53: 454.
[85]  Paredi P, Kharitonov S A, Barnes P J. Am. J. Respir. Crit. Care Med., 2000, 162: 1450.
[86]  Paredi P, Kharitonov S A, Leak D, Ward S, Cramer D, Barnes P J. Am. J. Respir. Crit. Care Med., 2000, 162: 369.
[87]  Olopade C O, Christon J A, Zakkar M, Hua C, Swedler W I, Scheff P A, Rubinstein I. Chest, 1997, 111: 1500.
[88]  Schubert J K, Muller W P, Benzing A, Geiger K. Intensive Care Med., 1998, 24: 415.
[89]  Risby T H, Sehnert S S. Free Radic. Biol. Med., 1999, 27: 1182.
[90]  Phillips M, Gleeson K, Hughes J M B, Greenberg J, Cataneo R N, Baker L, McVay W P. Lancet, 1999, 353: 1930.
[91]  Phillips M, Cataneo R N, Cummin A R, Gagliardi A J, Gleeson K, Greenberg J, Maxfield R A, Rom W N. Chest, 2003, 123: 2115.
[92]  Studer S M, Orens J B, Rosas I, Krishnan J A, Cope K A, Yang S, Conte J V, Becker P B, Risby T H. J. Heart Lung Transplant, 2001, 20: 1158.
[93]  Uasuf C G, Jatakanon A, James A, Kharitonov S A, Wilson N M, Barnes P J. J. Pediatr., 1999, 135: 569.
[94]  Yamara M, Sekizawa K, Ishizuka S, Monma M, Sasaki H. Eur. Respir. J., 1999, 13: 757.
[95]  Zayasu K, Sekizawa K, Okinaga S, Yamaya M, Ohrui T, Sasaki H. Am. J. Respir. Crit. Care Med., 1997, 156: 1140.
[96]  Antuni J D, Kharitonov S A, Hughes D, Hodson M E, Barnes P J. Thorax, 2000, 55: 138.
[97]  Singh D, Richards D, Knowles R G, Schwartz S, Woodcock A, Langley S, O’Connor B J. Am. J. Respir. Crit. Care Med., 2007, 176: 988.
[98]  Jobsis Q, Raatgeep H C, Hermans P W M, deJongste J C. Eur. Respir. J., 1997, 10: 519.
[99]  Fireman E, Shtark M, Priel I E, Shiner R, Mor R, Kivity S, Fireman Z. Inflammation, 2007, 30: 44.
[100]  Ho L P, Faccenda J, Innes J A, Greening A P. Eur. Respir. J., 1999, 13: 103.
[101]  Hunt J, Byrns R, Ignarro L, Gaston B. Lancet, 1995, 346: 1235.
[102]  Corradi M, Montuschi P, Donnelly L E, Hodson M E, Kharitonov S A, Barnes P J. Am. J. Respir. Crit. Care Med., 1999, 159: A628.
[103]  Horak F, Moeller A, Singer F, Straub D, Holler B, Helbich T H, Schneider B, Eichler I, Wildhaber J H, Hall G L. Pediatr. Pulmonol., 2007, 42: 1198.
[104]  Montuschi P. Clin. Chim. Acta, 2005, 356: 22.
[105]  Bean H D, Zhu J, Sengle C, Hill J E. J. Breath. Res., 2014, 8: 041001.
[106]  Gredilla R, Phaneuf S, Selman C, Kendaiah S, Leeuwenburgh C, Barja G. Ann. N Y Acad. Sci., 2004, 1019: 333.
[107]  Metodiewa D, Ko D?ka C. Neurotox. Res., 1999, 1: 197.
[108]  Hansen T K, Thiel S, Wouters P J, Christiansen J S, Van den Berghe G. J. Clin. Endocrinol. Metab., 2003, 88: 1082.
[109]  Izumi M, McDonald M C, Sharpe M A, Chatterjee P K, Thiemermann C. Shock, 2002, 18: 230.
[110]  Phillips M, Cataneo R N, Cheema T, Greenberg J. Clin. Chim. Acta, 2004, 344: 189.
[111]  Scholpp J, Schubert J K, Miekisch W, Geiger K. Clin. Chem. Lab Med., 2002, 40: 587.
[112]  Aghdassi E, Allard J P. Free Radic. Biol. Med., 2000, 28: 880.
[113]  Aghdassi E, Wendland B E, Steinhart A H, Wolman S L, Jeejeebhoy K, Allard J P. Am. J. Gastroenterol., 2003, 98: 348.
[114]  Kostikas K, Papatheodorou G, Psathakis K, Panagou P, Loukides S. Chest, 2003, 124: 1373.
[115]  Lases EeC, Duurkens V A M, Gerritsen W B M, Haas F J L M. Chest, 2000, 117: 999.
[116]  Phillips M, Cataneo R N, Greenberg J, Gunawardena R, Naidu A, Rahbari-Oskoui F. J. Lab Clin. Med., 2000, 136: 243.
[117]  Chan G C, Lau Y L, Yeung C Y. J. Paediatr. Child Health, 1998, 34: 447.
[118]  Tsang K W, Ip S K, Leung R, Tipoe G L, Chan S L, Shum I H, Ip M S, Yan C, Fung P C, Chan-Yeung M, Lam W. Lung, 2001, 179: 83.
[119]  Leung T F, Li C Y, Yung E, Liu E K, Lam C W, Wong G W. Pediatr. Pulmonol., 2006, 41: 87.
[120]  Xu F, Zou Z, Yan S, Li F, Kan H, Norback D, Wieslander G, Xu J, Zhao Z. J. Asthma., 2011, 48: 1001.
[121]  Leung T F, Ko F W, Wong G W. Ther. Adv. Respir. Dis., 2013, 7: 297.
[122]  Qiu G, Feng Y, Li X, Deng H, Dai X, Deng Q, Huang S, He M, Guo H, Zhang X, Hu F B, Wu T. Int. J. Cardiol., 2013, 168: e155.
[123]  Sun Y, Wang X M, Chen Y H, Zhu R X, Liao C C. Chin, Med, J, 2013, 126: 3240.
[124]  Xiang L, Fu Y N, Li Z, Ren Y X, Rao X C. Chin. J. Contemp. Pediatr. Dis., 2013, 15: 29.
[125]  Qiao H, Wang G F, Zhang H, Ding C M. Chin. J. Contemp. Pediatr. Dis., 2005, 28: 364.
[126]  Zhang H, Qiao H, Wang G F. Chin. J. Contemp. Pediatr. Dis.,2006, 29: 541.
[127]  Chen J L, Chen J R, Tao Y J, Cai Y Y, Tao G H. Chinese critical care medicine, 2008,20:357.
[128]  Li Y, Chongsuvivatwong V, Geater A, Liu A. Respiration, 2008, 76: 317.
[129]  Yang G H, Wang G F. Chin. Crit. Care Med., 2008, 20: 324.
[130]  Li Y, Chongsuvivatwong V, Geater A, Liu A. Sleep Med., 2009, 10: 95.
[131]  Wu C H, Cai S X, Zhao H J, Song B. J. South. Med. Univ., 2009, 29: 319.
[132]  Yang G H, Wang G F. Chin. Crit. Care Med., 2010, 22: 455.
[133]  Teng Y, Sun P, Zhang J, Yu R, Bai J, Yao X, Huang M, Adcock I M, Barnes P J. Chest, 2011, 140: 108.
[134]  Gong J, Zhu T, Kipen H, Wang G, Hu M, Ohman-Strickland P, Lu S E, Zhang L, Wang Y, Zhu P, Rich D Q, Diehl S R, Huang W, Zhang J J. J. Expo. Sci. Environ. Epidemiol., 2013, 23: 322.
[135]  Zou Y, Wang Y, Zhao C, Hu Y, Xu S, Ying K, Wang P, Chen X. J. Breath. Res., 2013, 7: 047101.
[136]  Yu J, Wang D, Wang L, Wang P, Hu Y, Ying K. AIP Conference Proceedings, 2009, 1137: 198.
[137]  Lu C R, Hu Y J, Chen E G, Qiu Y H, Ying K J. Chin. J. Tuberc. Respir. Dis., 2010, 33: 104.
[138]  Song G, Qin T, Liu H, Xu G B, Pan Y Y, Xiong F X, Gu K S, Sun G P, Chen Z D. Lung Cancer, 2010, 67: 227.
[139]  Wang Y, Hu Y, Wang D, Yu K, Wang L, Zou Y, Zhao C, Zhang X, Wang P, Ying K. Cancer Biomark., 2012, 11: 129.
[140]  Huo D Q, Xu Y H, Hou C J, Yang M, Fa H B. Sens. Actuators B Chem., 2014, 199: 446.
[141]  Xu H, Wei Y, Zhu L, Huang J, Li Y, Liu F, Wang S, Liu S. J. Chromatogr. A, 2014, 1324: 29.
[142]  Zou Y, Zhang X, Chen X, Hu Y, Ying K, Wang P. Cancer Biomark., 2014, 14: 371.
[143]  Xu Z Q, Broza Y Y, Ionsecu R, Tisch U, Ding L, Liu H, Song Q, Pan Y Y, Xiong F X, Gu K S, Sun G P, Chen Z D, Leja M, Haick H. Br. J. Cancer, 2013, 108: 941.
[144]  Wang C, Sun B, Guo L, Wang X, Ke C, Liu S, Zhao W, Luo S, Guo Z, Zhang Y, Xu G, Li E. Sci. Rep., 2014, 4: 5383.
[145]  Guo D, Zhang D, Li N, Zhang L, Yang J. IEEE Trans. Biomed. Eng., 2010, 57: 2753.
[146]  Guo D, Zhang D, Li N, Zhang L, Yang J. Diabetes Identification and Classification by Means of A Breath Analysis System. Second Intemational Conference, Medical Biometrics, (Eds. Zhang D, Sonka M). Springer, 2010. 52.
[147]  Guo D, Zhang D, Zhang L. Sens. Actuators B Chem., 2011, 158: 43.
[148]  Gong Y, Li E, Xu G, Wang H, Wang C, Li P, He Y. J. Int. Med. Res., 2009, 37: 1465.
[149]  Wang C, Li E, Xu G, Wang H, Gong Y, Li P, Liu S, He Y. Microchem. J., 2009, 91: 149.
[150]  Wang H, Li EY, Xu G W, Wang C S, Gong Y L, Li P. J. Int. Med. Res., 2009, 37: 1158.
[151]  Zhou Q, Li E, Wang X, Gong Y, Hua L, Wang W, Qu T, Li J, Liu Y, Wang C, Li H. Anal. Methods, 2014, 6: 698.
[152]  Li P, Li E, Xu G, Wang C, Gong Y, He Y. Eur. J. Anaesth., 2009, 26: 513.
[153]  Liu S, Shi J, Wang C, Li P, Gong Y, He Y, Xu G, Li J, Luo A, Li E. J. Breath. Res., 2012, 6: 026003.
[154]  Wang C, Shi J, Sun B, Liu D, Li P, Gong Y, He Y, Liu S, Xu G, Li J, Luo A, Li E. PLoS One, 2012, 7: e44940.
[155]  Wang C, Ke C, Wang X, Chi C, Guo L, Luo S, Guo Z, Xu G, Zhang F, Li E. Anal. Bioanal. Chem., 2014, 406: 4757.
[156]  Zhou M G, Liu Y, Li W W, Yuan X, Zhan X F, Li J, Duan Y X, Liu Y, Gao Z H, Cheng Y, Cheng S Q, Li H, Liang Y. Chin. Sci. Bull., 2014, 59: 1992.
[157]  Schubert J K, Miekisch W, Geiger K, Noldge-Schomburg G F E. Expert Rev. Mol. Diagn., 2004, 4: 619.
[158]  Knutson M D, Handelman G J, Viteri F E. Free Radic. Biol. Med., 2000, 28: 514.
[159]  Libardoni M, Stevens P T, Waite J H, Sacks R. J. Chromatogr. B Analyt Technol. Biomed. Life Sci., 2006, 842: 13.
[160]  Knutson M D, Viteri F E. Anal. Biochem., 1996, 242: 129.
[161]  陈建新 (Chen J X), 陈才 (Chen C), 盛国英 ( Sheng G Y), 王新明 (Wang X M), 傅家谟 (Fu J M), 刘子阳 (Liu Z Y), 刘淑莹 (Liu S Y). 高等学校化学学报 (Chemical Journal of Chinese Universities), 2000, 21: 45.
[162]  张晨 (Zhang C), 赵美萍 (Zhao M). 化学进展 (Progress in Chemistry), 2010, 22: 140.
[163]  Grote C, Pawliszyn J. Anal. Chem., 1997, 69: 587.
[164]  Mills G A, Walker V. J. Chromatogr. A, 2000, 902: 267.
[165]  Spinhirne J P, Koziel J A, Chirase N K. Biosyst. Eng., 2003, 84: 239.
[166]  Fiehn O. TrAC, 2008, 27: 261.
[167]  Hansel A, Jordan A, Holzinger R, Prazeller P, Vogel W, Lindinger W. Int. J. Mass Spectrom. Ion Process., 1995, 149/150: 609.
[168]  Smith D, Spanel P. Mass Spectrom. Rev., 2005, 24: 661.
[169]  Konvalina G, Haick H. Acc. Chem. Res., 2014, 47: 66.
[170]  Rudnicka J, Walczak M, Kowalkowski T, Jezierski T, Buszewski B. Sensor. Actuat. B-Chem., 2014, 202: 615.
[171]  Boshier P R, Marczin N, Hanna G B. J. Am. Soc. Mass Spectr., 2010, 21: 1070.
[172]  Spanel P, Smith D. Mass Spectrom. Rev., 2011, 30: 236.
[173]  Smith D, Spanel P, Fryer A A, Hanna F, Ferns G A A. J. Breath Res., 2011, 5: 022001.
[174]  ?paněl P, Davies S, Smith D. Rapid Commun. Mass Spectrom., 1999,13: 1733.
[175]  Li J, Peng Y, Duan Y. Critical Rev. Oncol./Hematol., 2013, 87: 28.
[176]  Kasapovic J, Pejic S, Todorovic A, Stojiljkovic V, Pajovic S B. Cell Biochem. Funct., 2008, 26: 723.
[177]  Mense S M, Remotti F, Bhan A, Singh B, El-Tamer M, Hei T K, Bhat H K. Toxicol. Appl. Pharmacol., 2008, 232: 78.
[178]  Ambrosone C B. Antioxid. Redox Signal, 2000, 2: 903.
[179]  Hietanen E, Bartsch H, Bereziat J C, Camus A M, McClinton S, Eremin O, Davidson L, Boyle P. Eur. J. Clin. Nutr., 1994, 48: 575.
[180]  Ebeler S E, Clifford A J, Shibamoto T. J. Chromatogr. B, 1997, 702: 211.
[181]  Phillips M, Cataneo R N, Ditkoff B A, Fisher P, Greenberg J, Gunawardena R, Kwon C S, Rahbari-Oskoui F, Wong C. Breast J., 2003, 9: 184.
[182]  Phillips M, Cataneo R N, Ditkoff B A, Fisher P, Greenberg J, Gunawardena R, Kwon C S, Tietje O, Wong C. Breast Cancer Res. Treat., 2006, 99: 19.
[183]  Phillips M, Cataneo R N, Saunders C, Hope P, Schmitt P, Wai J. J. Breath. Res., 2010, 4: 026003.
[184]  Shuster G, Gallimidi Z, Reiss A H, Dovgolevsky E, Billan S, Abdah-Bortnyak R, Kuten A, Engel A, Shiban A, Tisch U. Breast Cancer Res. Treat., 2011, 126: 791.
[185]  Barnes P J, Chowdhury B, Kharitonov S A, Magnussen H, Page C P, Postma D, Saetta M. Am. J. Respir. Crit. Care. Med., 2006, 174: 6.
[186]  Barnes P J, Dweik R A, Gelb A F, Gibson P G, George S C, Grasemann H, Pavord I D, Ratjen F, Silkoff P E, Taylor D R, Zamel N. Chest, 2010, 138: 682.
[187]  Ricciardolo F L M, Sterk P J, Gaston B, Folkerts G. Physiol. Rev., 2004, 84: 731.

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