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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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分子阵列研究进展
, PP. 1779-1787
Keywords: 分子阵列,固定化技术,原位合成,非原位合成,化学印刷,应用
Abstract:
小分子化合物可以调节生物学过程，是研究活性生物大分子（特别是蛋白质）以及药物的重要工具，而高通量筛选是发现活性分子的重要方法。分子阵列是近年来新出现的一种高通量筛选技术，上面含有成千上万种组合合成的化合物以及天然产物，可以用于发现新的先导化合物，以及筛选已有的先导化合物。现在分子阵列已经成功应用于蛋白分析、先导化合物的发现等许多领域。本文综述了近年来分子阵列的构建过程，原位合成、非原位合成等各种固定化策略以及荧光免疫检测，表面等离子体共振成像技术等检测手段，并介绍了化学分子印刷阵列方法，最后总结了分子阵列的应用，并对分子阵列在我国中药发展等有方面将起到的潜在作用作了展望。
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