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OALib Journal期刊
ISSN: 2333-9721
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国内心、脑、肿瘤放射性诊断药物的研究进展
, PP. 1485-1492
Keywords: 放射性药物,显像剂,诊断和治疗放射性药物,PET
Abstract:
近年来,我国放射性药物的发展很迅速,并且在医学诊治疾病中及基础研究中占据越来越重要的地位。放射性诊断药物是指用于体内进行医学诊断的含放射性核素标记的化合物或生物制剂。本文介绍了国内近年放射性诊断药物在神经系统、心血管、肿瘤等方面的研究进展和应用前景,并提出了目前国内放射性药物研究存在的主要问题和今后可能的发展方向大力发展PET药物,重点是设计和研制各类脑受体显像剂、有特异性受体结合的肿瘤显像剂和心肌代谢显像剂等。[1]ZhangJ,WangX,LiuJ.J.Label.Compd.Radiopharm.,2004,47647-655[2]LuJ,WangX.J.Label.Compd.Radiopharm.,2009,52183-188[3]ChenYP,ZhangL,LiuB.Bioorg.Med.Chem.Lett.,2008,181442-1445[4]CuiM,TangRK,LiaZJ,RenHY,LiuB.Bioorg.Med.Chem.Lett.,2011,211064-1068[5]YangY,ZhuL,CuiMC,TangRK,ZhangHB.Bioorg.Med.Chem.Lett.,2010,205337-5344[6]DuanXH,QiaoJP,YangY,CuiMC,ZhouJN,LiuBL.Bioorg.Med.Chem.Lett.,2010,181337-1343[7]MouTT,JingH,YangWJ,ZhangXZ.AppliedRadiationandIsotopes,2009,672013-2018[8]TianH,YinD,ZhangL,WangL,ZhangC,WangM,WuC,LiG,WangY.AppliedRadiationandIsotopes,2005,63333-342[9]张锦明(ZhangJM),田嘉禾(TianJH),郭喆(GuoZ),王武尚(WangWS),刘伯里(LiuBL).同位素(JournalofIsotop),2008,21105-109[10]蒋燕(JiangY),刘伯里(LiuBL).科学通报(ChineseScienceBulletin),2001,46(9)727-730[11]RogerA,RogerS,AndreE.J.Am.Chem.Soc.,1998,1207987-7988[12]ChenXJ,GuoYH,ZhangQ,LiuBL.J.Organomet.Chem.,2008,6931822-1828[13]蒋燕(JangY),刘伯里(LiuBL).科学通报(ChineseScienceBulletin),2001,46(9)727-730[14]张现忠(ZhangXZ),王学斌(WangXB),温海涛(WenHT).高等学校化学学报(ChemicalJournalofChineseUniversities),2003,2421-24[15]楚进锋(ChuJF),李彬(LiB),孔德靖(KongDJ),王学斌(WangXB),张俊波(ZhangJB),王金城(WangJC),米宏志(MiHZ),赵建冬(ZhaoJD).高等学校化学学报(ChemicalJournalofChineseUniversities),2005,261014-1017[16]ChuJF,LiB,KongDJ,WangXB,ZhangJB.J.Radioanal.Nucl.Chem.,2006,269175-179[17]ZhangJB,SongZX,ChuJF,WangXB.AppliedRadiationandIsotopes,2009,671661-1663[18]季顺东(JiSD),方纬(FangW),周俊东(ZhouJD),何作祥(HeZX),刘秀杰(LiuXJ),阮长耿(RuanCG),赵明(ZhaoM).核技术(NuclearTechniques),2007,30679-682[19]ChuTW,ZhangY,LiuXQ,WangY,HuSW,WangXY.AppliedRadiationandIsotopes,2004,60845-850[20]MadarI,RavertHT,DuY,HiltonJ,VolokhL,DannalsRF,FrostJJ,HareJM.J.Nucl.Med.,2006,471359-1336[21]ChengZ,SubbarayanM,ChenX,GambhirSS.J.Label.Compd.Radiopharm.,2005,48131-137[22]MouTT,JingHH,YangWJ,ZhangX.Bioorg.Med.Chem.,2010,181312-1320[23]ChenX,LiL,LiuF,Liu,BL.Bioorg.Med.Chem.Lett.,2006,165503-5506[24]QiaoYL,HeY,ZhangST,LiGX,LiuH,XuJG,WangX,QiCM,PengC.Bioorg.Med.Chem.Lett.,2009.194873-4877[25]唐刚华(TangGH),唐小兰(TangXL),罗磊(LuoL).核技术(NuclearTechniques),2003,6619-622[26]王明伟(WangMW),尹端沚(YingTZ),汪勇先(WangYX),李俊玲(LiJL),张岚(ZhangL),周伟(ZhouW).核技术(NuclearTechniques),2005,28654－658[27]RossiD,ZlotnikA.Annu.Rev.Immunol.,2000,18217-242[28]韩彦江(HanYJ),程登峰(ChengDF),张岚(ZhangL).核技术(NuclearTechniques),2010,33297-302[29]ZhangJ,TianJ,ShenL.CN101780286,2010[30]ZhangJM,TianJH,LiTR,GuoHY,ShenL.Chin.Chem.Lett.,2010,21461-463[31]ZhangYQ,SunYH,XuXP,ZhangXZ,ZhuH,HuangLL.QiYJ,Shen
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