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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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唾液酸糖苷化方法学研究*
, PP. 91-100
Keywords: 唾液酸,糖苷化,N-乙酰神经氨酸
Abstract:
唾液酸是一类酸性九碳糖，通过α-糖苷键的方式广泛分布于生物体系内糖缀合物和多聚唾液酸中而发挥着重要的生物学功能。如何有效地构建唾液酸α-糖苷键，合成天然的含有唾液酸的糖缀合物、多聚唾液酸及其衍生物，是糖化学研究的热点和难点。近年来，人们基于唾液酸的结构特点，一方面通过在C2位引入易离去的基因，发展了直接成苷的方法，显著提高成苷的产率；另一方面，通过对C1和C3位引入辅助基因，发展了间接成苷的方法，提高了成苷的α-选择性。本文主要从直接成苷和间接成苷两个方面对目前研究的唾液酸糖苷化的化学方法学进行综述。
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