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化学进展  2010 

药物共晶研究进展*

, PP. 829-836

Keywords: 共晶,晶体设计,共晶形成原理

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Abstract:

相同药物的不同固体形态往往有不同的理化性质、药效以及制剂制备工艺。常见的固体形态如溶剂化物、盐,因为种类少或适用的药物少而在应用上受到一定的限制,所以种类多、适用范围广的共晶作为可设计的药物固体形态近年来逐渐受到关注。本文介绍了药物共晶的研究进展,包括其形成原理、设计思路、性质以及制备方法,共晶在药物研究领域有很好的应用前景。

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