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海洋科学  2007 

恩诺沙星在菲律宾蛤仔体内的消除规律研究

, PP. 32-36

Keywords: 菲律宾蛤仔(Ruditapes,philippinarum),恩诺沙星,消除

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Abstract:

以5mg/L恩诺沙星浸浴菲律宾蛤仔(Ruditapesphilippinarum)24h,取血液、鳃、内脏团、足、闭壳肌5种组织,反相高效液相色谱法测定其中的药物浓度。结果表明,恩诺沙星按一级动力学过程从体内消除,在5种组织中消除速率快慢不一,其在菲律宾蛤仔血液、鳃、内脏团、足、闭壳肌中的消除曲线方程分别为c=6.995e-0.0853t,c=2.7957e-0.1177t,c=1.539e-0.1013t,c=1.7015e-0.1535t,c=2.010e-0.1414t,消除半衰期T1/2分别为6.284,5.889,6.483,4.516,3.679h。恩诺沙星在水产品中的最大残留限量为50μg/kg,在本实验条件下,建议临床休药期不小于2d。

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