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海洋科学  2006 

凡纳滨对虾摄食诺氟沙星强化卤虫的药代动力学研究

, PP. 45-51

Keywords: 凡纳滨对虾(Litopenaeus,vannamei),诺氟沙星,卤虫(Artemia),药代动力学

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Abstract:

应用高效液相色谱法研究了凡纳滨对虾(Litopenaeusvannamei)摄食诺氟沙星强化卤虫(Artemia)的药物代谢动力学。结果表明:强化4~8h,卤虫体内的药物质量浓度达到最高,此后卤虫体内药物摄入和排除达到一个动态平衡;温度影响诺氟沙星在卤虫体内半衰期:体长3mm和6mm的卤虫,在4,16,28℃时的半衰期分别为51.33,19.29,18.64h和39.67,13.26,12.6h。对虾摄食诺氟沙星强化的卤虫后,对虾组织中药物质量浓度经时过程符合一级吸收二室开放模型;投喂剂量对Tmax和Cmax影响较大,当对虾给药质量分数分别为800,400,200mg/kg时,肌肉中给药后出现最高血药的时间或达峰时间分别为0.403,0.540,0.481h;肝胰脏中给药后出现最高血药的时间或达峰时间分别为0.826,1.839,1.469h;肌肉中给药后的最高血药质量浓度分别为98.943,46.752,10.887mg/L;肝胰脏中给药后的最高血药质量浓度分别为738.267,597.352,415.268mg/L。药物在对虾肌肉的消除半衰期(约26.688h)明显长于肝胰脏中消除半衰期(约13.988h)。

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