全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

聚肌胞注射液对罗曼蛋鸡免疫机能的影响

DOI: 10.7685/j.issn.1000-2030.2008.04.022, PP. 119-123

Keywords: 聚肌胞,,免疫机能

Full-Text   Cite this paper   Add to My Lib

Abstract:

选用罗曼蛋公鸡120羽,随机分为4组,聚肌胞用药低剂量组、中剂量组和高剂量组,聚肌胞用药组分别按0.5、1.0和2.0mg?kg-1剂量一次性胸肌注射聚肌胞注射液,对照组注射生理盐水。所有处理组注射容量均为0.5mL。用药后分别在第2、6、10天检测血液生化指标,第2、10天检测免疫学指标。结果显示,用药后第2天,高剂量组血清内总蛋白含量显著高于对照组,高剂量组淋巴细胞数显著高于对照组(P<0.05);高剂量组和中剂量组血清内球蛋白含量、T细胞总数E-玫瑰花环形成率、法氏囊指数均显著高于对照组(P<0.05)。研究结果表明,聚肌胞可以提高罗曼蛋鸡的免疫机能。

References

[1]  Davies D R,Rich A.The formation of a helical complex between polyinosinic acid and polycytidylic acid[J].American Chemistry Society.1958,80(4):1003-1004
[2]  费明.聚肌胞治疗流行性腮腺炎的初步观察[J].实用口腔医学杂志.2005,21(3):296
[3]  Salem M L,EL-Naggar S A,Kadima A.The adjuvant effects of the toll-like receptor 3 ligand polyinosinic-cytidylic acid poly(I:C)on antigen-specific CD8+ T cell responses are partially dependent on NK cells with the induction of a beneficial cytokine milieu[J].Vaccine.2006,24:5119-5132
[4]  杜念兴.兽医免疫学[M].北京:中国农业出版社.2001:17,80-85,210
[5]  Carter W A,Strayer D R,Hubbell H R.Preclinical studies with Ampligen(mismatched double-stranded RNA)[J].Journal of Biological Response Modifiers.1985,4(5):495-502
[6]  Verdik R M,Mutis T,Esendam B.Polyriboinosinic polyribocytidylic acid(poly(I:C[J].Journal of Immunology.1999,163(1):57-61
[7]  Chirigos M A,Papademetriou V,Bartocci A.Immune response modifying activity in mice of polyinosinic:polycytidylic acid stabilized with poly-L-lysine,in carboxymethylcellulose[poly-ICLC][J].International Journal of Immunopharmacology.1981,3(4):329-337
[8]  Cunningham C,Campion S,Teeling J.The sickness behaviour and CNS inflammatory mediator profile induced by systemic challenge of mice with synthetic double-stranded RNA(poly I:C)[J].Brain Behavior and Immunity.2007,21:490-502
[9]  胡奇伟,王春雄,过世东.血浆蛋白粉对断奶仔猪生长性能及血液生化指标的影响[J].粮食与饲料工业.2005(11):35-37
[10]  崔恒敏,赵翠燕,黎得兵.高锌对雏鸡免疫功能影响的研究[J].畜牧兽医学报.2005,36(3):240-245
[11]  Talmadge J E,Adams J,Phillips H.Immunomodulatory effects in mice of polyinosinic-polycytidylic acid complexed with poly-L-lysine and carboxymethylcellulose[J].Cancer Research.1985,45(3):1058-1065
[12]  Traynor T R,Majde J A,Bohnet S G.Sleep and body temperature responses in an acute viral infection model are altered in interferon type I receptor-defcient mice[J].Brain Behavior and Immunity.2006,20:290-299
[13]  Maluish A E,Reid J W,Crisp E A.Immunomodulatory effects of poly(I,C)-LC in cancer patients[J].Journal of Biological Response Modifiers.1985,4(6):656-663
[14]  李绍刚.聚肌胞联合西咪替丁治疗带状疱疹临床效果观察[J].广西医学.2006,28(6):939

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133