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脱氢表雄酮对幼年大鼠脂类代谢的影响

DOI: 10.7685/j.issn.1000-2030.2008.03.022, PP. 113-116

Keywords: 脱氢表雄酮,脂类代谢,大鼠,幼年期

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Abstract:

选用健康雄性SD大鼠40只,随机分为4组,每组10只。对照组腹腔注射50%乙醇+50%丙二醇混合液,3个试验组分别经腹腔注射1、5和10mg.kg-1的脱氢表雄酮(DHEA)溶液。每隔1d注射1次,连续7次。试验结果表明,DHEA能够降低幼年期大鼠腹脂率、血清甘油三酯(TG)、非酯化脂肪酸(NEFA)的水平,对血清中胆固醇(TC)水平没有显著影响;高剂量的DHEA可显著降低肝脏组织中脂蛋白脂酶(LPL)和肝脂酶(HL)的活性。不同浓度的DHEA均可显著降低血清中胰岛素和TNF-α的水平,具有增加胰高血糖素的趋势。DHEA能显著降低肝脏中糖原、TC水平,对TG没有影响,但DHEA可显著增加肝脏中Na+-K+-ATP酶活性。提示,DHEA具有降低幼年期大鼠脂肪蓄积的作用。

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