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以黄独乙素和儿茶素为指标成分研究黄药子 - 当归配伍组合

Keywords: 黄药子,配伍,黄独乙素,儿茶素,HPLC-UV

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Abstract:

采用HPLC-UV法研究不同比例黄药子-当归配伍组合中黄独乙素及儿茶素的质量分数.采用95%乙醇对黄药子-当归配伍组合进行提取,经乙酸乙酯萃取后,测定黄药子及各配伍组合中黄独乙素及儿茶素质量分数.结果表明黄独乙素和儿茶素分别在10~200μg/mL及200~1200μg/mL范围内呈良好线性关系,平均回收率分别为89.4%及92.8%.黄药子单煎液中黄独乙素质量分数2.90mg/g,儿茶素质量分数为0.78mg/g,黄药子-当归以1:1,1:2,2:1配伍时,各组中黄独乙素质量分数分别为1.01,2.19,2.04mg/g,表明黄药子与当归以1:1比例配伍后,致肝毒性成分黄独乙素质量分数最低.各组中儿茶素质量分数分别为0.35,0.30,0.43mg/g,即1:2的配伍比例中儿茶素质量分数最低.结果表明当归的药味比例显著影响黄药子中主要成分的质量分数,这些质量分数变化或与当归与黄药子配伍后药效增强、毒性降低有关.

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