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维生素E补充对心脑血管疾病影响随机对照试验meta分析

DOI: 10.11847/zgggws2015-31-11-40, PP. 1497-1501

Keywords: 维生素E,心脑血管疾病事件,影响,随机对照试验,meta分析

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Abstract:

?目的探讨维生素E补充剂对心脑血管疾病事件(中风、心肌梗死、短暂性脑缺血发作)发生的影响,为心脑血管疾病的防治提供参考依据。方法检索Pubmed、EMBASE、OVID、Healthstar、Cochranedatabase、GoogleScholar、ScienceCitationIndex等外文数据库和万方数据知识平台、中国知网系列数据库、中国生物医学文献数据库、维普期刊资源整合服务系统等中文数据库,全面收集1980-2014年间维生素E补充与心脑血管疾病事件发生关系的随机对照试验文献,采用Revman5.1软件对纳入的文献进行Meta分析。结果最终纳入13篇英文文献,累计维生素E组干预人数62871例,安慰剂组对照人数62837例;Meta分析结果显示,维生素E补充对心脑血管疾病事件的发生无显著影响(RR=0.99,95%CI=0.96~1.02),对中风的发生无显著影响(RR=1.03,95%CI=0.96~1.10),对心肌梗死的发生无显著影响(RR=0.99,95%CI=0.93~1.04),对短暂性脑缺血发作无显著影响(RR=0.94,95%CI=0.82~1.09);亚组分析结果显示,性别、随访时间、是否有其他干预措施和维生素E的剂量均对心脑血管疾病事件的发生无显著影响(均P>0.05)。结论补充维生素E对心脑血管疾病事件的发生无显著影响。

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