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振动运动对雌性大鼠化疗相关性疲乏影响

DOI: 10.11847/zgggws2015-31-10-12, PP. 1276-1279

Keywords: 振动运动,化疗性疲乏,白细胞介素1β(IL-1β),肿瘤坏死因子α(TNFα),白细胞介素6(IL-6)

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Abstract:

?目的探讨振动运动对化疗相关性疲乏的作用及可能机制。方法60只雌性SD大鼠随机分为对照组和实验组。将实验组大鼠腹腔注射2.5mg/kg盐酸表柔比星,累积剂量达15mg/kg建立化疗疲乏模型后,随机分为模型组,低、中、高运动量组(15Hz、5min,25Hz、15min,35Hz、45min),每组10只;每周运动6d,连续4周。末次运动前采用鼠尾悬挂实验测疲乏程度,末次运动结束后即刻采血,酶联免疫吸附试验测定血清白细胞介素1β(IL-1β)、肿瘤坏死因子α(TNFα)、IL-6水平。结果与对照组比较,模型组大鼠悬尾不动时间[(197.40±23.74)s]延长(P<0.01),血清IL-1β、TNFα水平[分别为(748.17±34.71)、(66.46±0.98)pg/mL]升高(P<0.01);与模型组比较,中运动量组大鼠悬尾不动时间[(167.90±28.12)s]缩短(P<0.05),中、高运动量组大鼠血清IL-1β、TNFα水平[分别为(561.72±48.16)、(64.60±0.65)与(567.17±27.50)、(64.54±0.55)pg/mL]下降(P<0.01),低、中、高运动量组大鼠血清IL-6水平[分别为(89.07±3.22)、(118.40±5.10)、(130.69±3.87)pg/mL]升高(P<0.05)。结论振动运动可减轻雌性大鼠化疗相关性疲乏,其机制可能与下调炎症因子水平、上调抗炎因子水平有关。

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