Neuschwander-Tetri BA.Hepatic lipotoxicity and the pathogenesis of non-alcoholic steatohepatitis:the central role of nontriglyceride fatty acid metabolites[J].Hepatology,2010,52:774-788.
[5]
Cusi K.Role of insulin resistance and lipotoxicity in non-alcoholic steatohepatitis[J].Clin Liver Dis,2009,13(4):545-563.
Finn PF,Dice JF.Proteolytic and lipolytic responses to starvation[J].Nutrition,2006,22(7-8):830-844.
[8]
Czaja MJ.Autophagy in health and disease.2.Regulation of lipid metabolism and storage by autophagy:pathophysiological implications[J].Am J Physiol-Cell Ph,2010,298(5):C973-978.
Mei S,Ni HM,Manley S,et al.Differential roles of unsaturated and saturated fatty acids on autophagy and apoptosis in hepatocytes[J].J Pharmacol Exp Ther,2011,339:487-498.
[11]
Hernandez-Gea V,Ghiassi-Nejad Z,Rozenfeld R,et al.Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues[J].Gastroenterology,2012,142:938-946.
Cuervo AM,Bergamini E,Brunk UT,et al.Autophagy and aging:the importance of maintaining''clean'' cells[J].Autophagy,2005,1(3):131-140.
[16]
范建高,曾民德.代谢综合症与脂肪性肝病[M].北京:人民卫生出版社,2005:204.
[17]
Hara T,Nakamura K,Matsui M,et al.Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice[J].Nature,2006,441(7095):885-889.
[18]
Wang Y,Singh R,Xiang Y,et al.Macroautophagy and chaperone-mediated autophagy are required for hepatocyte resistance to oxidant stress[J].Hepatology,2010,52(1):266-277.
[19]
Farre JC,Manjithaya R,Mathewson RD,et al.PpAtg30 tags peroxisomes for turnover by selective autophagy[J].Dev Cell,2008,14(3):365-376.
Rodriguez-Enriquez S,Kai Y,Maldonado E,et al.Roles of mitophagy and the mitochondrial permeability transition in remodeling of cultured rat hepatocytes[J].Autophagy,2009,5(8):1099-1106.
[22]
Singh R,Wang Y,Xiang Y,et al.Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance[J].Hepatology,2009,49(1):87-96.
[23]
Maher JJ,Leon P,Ryan JC.Beyond insulin resistance:innate immunity in nonalcoholic steatohepatitis[J].Hepatology,2008,48(2):670-678.
[24]
Saitoh T,Akira S.Regulation of innate immune responses by autophagy-related proteins[J].J Cell Biol,2010,189(6):925-935.
[25]
Saitoh T,Fujita N,Jang MH,et al.Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production[J].Nature,2008,456(7219):264-268.
[26]
Rivera CA,Adegboyega P,van Rooijen N,et al.Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis[J].J Hepatol,2007,47(4):571-579.
[27]
Fukada H,Yamashina S,Izumi K,et al.Suppression of autophagy sensitizes Kupffer cells to endotoxin[J].Hepatol Res,2012,42:1112-1118.
[28]
Mandrekar P,Szabo G.Signalling pathways in alcohol-induced liver inflammation[J].J Hepatol,2009,50:1258-1266.
[29]
Hidvegi T,Ewing M,Hale P,et al.An autophagy-enhancing drug promotes degradation of mutantβ1-antitrypsin Z and reduces hepatic fibrosis[J].Science,2010,329(5988):229-232.
[30]
Yamaguchi K,Yang L,McCall S,et al.Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis[J].Hepatology,2007,45(6):1366-1374.
[31]
Imai Y,Varela GM,Jackson MB,et al.Reduction of hepatosteatosis and lipid levels by an adipose differentiation-related protein antisense oligonucleotide[J].Gastroenterology,2007,132(5):1947-1954.
[32]
Kroemer G,Marino G,Levine B.Autophagy and the integrated stress response[J].Mol Cell,2010,40:280-293.
