| [1] | Qian S Z， Xu Y， Zhang J W. Recent progress in research on Tripterygium： A male antifertility plant[J]. Contraception， 1995， 51(2)：121.
|
| [2] | Kupchan S M， Court W A ， Dailey R G， et al. Triptolide and tripdiolide， novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii [J]. J Am Chem Soc，1972， 94(20)：7194.
|
| [3] | Wei Y S, Adachi I. Inhibitory effect of triptolide on colony formation of breast and stomach cancer cell lines [J]. Acta Pharmacol Sin, 1991, 12(5):406.
|
| [4] | Yang S， Chen J， Guo Z， et al. Triptolide inhibits the growth and metastasis of solid tumors [J]. Mol Cancer Ther， 2003， 2 (1)：65.
|
| [5] | Shamon L A， Pezzuto J M， Graves J M， et al. Evaluation of the mutagenic， cytotoxic， and antitumor potential of triptolide， a highly oxygenated diterpene isolated from Tripterygium wilfordii[J]. Cancer Lett， 1997， 112(1)：113.
|
| [6] | Frese S， Pirnia F， Miescher D， et al. PG490-mediated sensitization of lung cancer cells to Apo2L/TRAIL-induced apoptosis requires activation of ERK2 [J]. Oncogene， 2003， 22 (35)： 5427.
|
| [7] | Chan E W， Cheng S C， Sin F W， et al. Triptolide induced cytotoxic effects on human promyelocytic leukemia， T cell lymphoma and human hepatocellular carcinoma cell lines [J]. Toxicol Lett， 2001， 122(1)：81.
|
| [8] | Tengchaisri T ， Chawengkirttikul R ， Rachaphaew N ， et al. Antitumor activity of triptolide against cholangiocarcinoma growth in vitro and in hamsters [J]. Cancer Lett，1998， 133(2)：169.
|
| [9] | Zhou G X， Ding X L， Huang J F， et al. Apoptosis of human pancreatic cancer cells induced by Triptolide[J]. World J Gastroentero， 2008， 14(10)：1504.
|
| [10] | Kiviharju T M， Lecane P S， Sellers RG， et al. Antiproliferative and proapoptotic activities of triptolide (PG490)， a natural product entering clinical trials， on primary cultures of human prostatic epithelial cells[J]. Clin Cancer Res， 2002， 8(8)：2666.
|
| [11] | Fidler J M， Li K， Chung C， et al. PG490-88， a derivative of triptolide， causes tumor regression and sensitizes tumors to chemotherapy [J]. Mol Cancer Ther， 2003， 2(9)：855.
|
| [12] | Chen C N， Hsieh F J， Cheng Y M， et al. Expression of inducible nitric oxide synthase and cyclooxygenase-2 in angiogenesis and clinical outcome of human gastric cancer [J]. J Surg Oncol，2006， 94(3)： 226.
|
| [13] | Cianchi F， Cortesini C， Fantappie O， et al. Cyclooxygenase-2 activation mediates the proangiogenic effect of nitric oxide in colorectal cancer [J]. Clin Cancer Res，2004， 10(8)： 2694.
|
| [14] | Tong X M， Zheng S E， Jin J， et al. Triptolide inhibits cyclooxygenase-2 and inducible nitric oxide synthase expression in human colon cancer and leukemia cells [J]. Acta Biochim Biophys Sin， 2007， 39(2)：85.
|
| [15] | Westerheide S D， Kawahara T A， Orton K， et al. Triptolide， an inhibitor of the human heat shock response that enhances stress-induced cell death [J]. J Biol Chem， 2006， 281(14)：9616.
|
| [16] | Lee K Y， Chang W， Qiu D， et al. PG490 (triptolide) cooperates with tumor necrosis factor-alpha to induce apoptosis in tumor cells [J]. J Biol Chem， 1999， 274(19)：13451.
|
| [17] | Lee K Y， Park J S， Jee Y K， et al. Triptolide sensitizes lung cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by inhibition of NF-kappaB activation [J]. Exp Mol Med， 2002， 34(6)：462.
|
| [18] | Lou Y J， Jin J， Wang Y G， et al. Triptolide inhibits transcription factor NF-kappaB and induces apoptosis of multiple myeloma cells [J]. Leuk Res， 2005， 29(1)：99.
|
| [19] | Qiu D M， Zhao G H， Aoki Y K， et al. Immunosuppressant PG490(triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-kappaB transcriptional activation [J]. J Biol Chem， 1999， 274(19)：13443.
|
| [20] | Jiang X H， Wong B C， Lin M C， et al.Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-kappaB activation in gastric cancer cells [J]. Oncogene， 2001， 20(55)： 8009.
|
| [21] | Choi Y J， Kim T G， Kim Y H， et al. Immunosuppressant PG490 (triptolide) induces apoptosis through the activation of caspase-3 and down-regulation of XIAP in U937 cells [J]. Biochem Pharmacol， 2003， 66(2)：273.
|
| [22] | Lala P K, Chakraborty C. Role of nitric oxide in carcinogenesis and tumour progression [J]. Lancet Oncol, 2001, 2(3): 149.
|
| [23] | Hu K B， Liu Z H， Guo X H， et al. Triptolide inhibits vascular endothelial growth factor expression and production in endothelial cells[J].Acta Pharmacol Sin，2000，22(7)：651.
|
| [24] | 丁怡,张建成,侯立军,等.雷公藤甲素对血管生成的抑制作用[J].生物医学工程学杂志,2005,22(4):778.
|
| [25] | 曹永亮,张杰,赵庆亮,等.雷公藤内酯醇对血管内皮细胞t-PA、PAI-1蛋白表达的影响[J].眼科新进展, 2007,27(1):15.
|
| [26] | 杨盛波,文海泉,张桂英,等. 雷公藤内酯醇对纤维肉瘤HT-1080细胞表达基质金属蛋白酶的影响[J].实用预防医学,2008,15(4):1015.
|
