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毛萼獐牙菜化学成分的研究

Keywords: 毛萼獐牙菜,口山酮,裂环烯醚萜

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Abstract:

目的:对龙胆科Gentianaceae獐牙菜属植物毛萼獐牙菜SwertiahispidicalyxBurk.的干燥全草进行化学成分研究。方法:采用各种柱色谱进行分离纯化,通过波谱数据分析(MS,1H-,13C-NMR)进行结构鉴定。结果:从乙酸乙酯萃取部分分离鉴定了11个化合物,其中2个口山酮,2个裂环烯醚萜,2个三萜,2个甾体,以及3个其他类化合物,它们分别鉴定为1,3,5,8-四羟基口山酮(1,3,5,8-tetrahydroxyxanthone,1),1,5,8-三羟基-3-甲氧基口山酮(1,5,8-trihydroxy-3-methoxyxanthone,2),龙胆内酯(gentiolactone,3),獐牙菜苦苷(swertiamarin,4),3,4-dihydro-1H,6H,8H-naphthodipyrano-1,8-dione(5),(+)-丁香脂素6)],松柏醛(trans-coniferylaldehyde,7),山楂酸(maslinicacid,8),齐墩果酸(oleanolicacid,9),胡萝卜苷(daucosterol,10),β-谷甾醇(β-sitosterol,11)。结论:化合物1~11均为首次从毛萼獐牙菜中分离得到。

References

[1]  中科院中国植物志编委会. 中国植物志. 第62卷[M]. 北京: 科学出版社,1988: 392.
[2]  中国药典. 一部[S]. 2010: 182.
[3]  Brahmachari G,Mondal S,Gangopadhyay A,et al. Swertia (Gentianaceae): chemical and pharmacological aspects[J]. Chem Biodiver,2004,1(11): 1627.
[4]  Wu Y R,Ma Y B,Zhao Y X,et al. Two new quaternary alkaloids and anti-hepatitis B virus active constituents from Corydalis saxicola[J]. Planta Med,2007,73(8): 787.
[5]  Geng C A,Jiang Z Y,Ma Y B,et al. Swerilactones A and B,anti-HBV new lactones from a tradtional Chinese herb: Swertia mileensis as a treatment for viral hepatitis[J]. Org Lett,2009,11(18): 4120.
[6]  Geng C A,Zhang X M,Shen Y,et al. Swerilactones C and D,anti-HBV new lactones from a traditional Chinese herb: Swertia mileensis[J]. Org Lett,2009,11(21): 4838.
[7]  Geng C A,Zhang X M,Ma Y B,et al,Swerilactones E-G,three unusual lactones from Swertia mileensis[J]. Tetrahedron Lett,2010,51(18): 2483.
[8]  Geng C A,Zhang X M,Ma Y B,et al. Three new secoiridoid glycoside dimers from Swertia mileensis[J]. J Asian Nat Prod Res,2010,12(6): 542.
[9]  李旭山,江志勇,王福生,等. 青叶胆化学成分研究[J]. 中国中药杂志,2008,33(23): 2790.
[10]  Suhr J H,Arends P,Jensen B. Gentiolactone,a secoiridoid dilactone from Gentiana purpurea[J]. Phytochemistry,1978,17: 135.
[11]  周凌云,张祥华,陈昌祥. 丽江产红景天的化学成分[J]. 天然产物研究与开发,2004,16(5): 410.
[12]  Doong S L,Tsai C H,Schinazi R F,et al. Inhibition of the replication of hepatitis B virus in vitro by 2,3-dideoxy-3-thiacytidine and related analogues[J]. Proc Natl Acad Sci Unit States Am,1991,88: 8495.
[13]  Jiang Z Y,Zhang X M,Zhang F X,et al. A new triterpene and anti-hepatitis B virus active compounds from Alisma orientalis[J]. Planta Med,2006,72(10): 951.
[14]  Yan M H,Cheng P,Jiang Z Y,et al. Periglaucines A-D,anti-HBV and -HIV-1 alkaloids from Pericampylus glaucus[J]. J Nat Prod,2008,71(5): 760.
[15]  Chen P,Ma Y B,Yao S Y,et al. Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida[J]. Bioorg Med Chem Lett,2007,17(19): 5316.
[16]  段朝辉,石宝俊,吴立宏,等. 长梗秦艽的化学成分[J]. 中国天然药物,2007,5(6): 417.
[17]  Kitanov G M,Spassov S L. A naphthodipyranodione from Gentiana asclepiadea[J]. Phytochemistry,1992,31(3): 1067.
[18]  Chen C Y,Wu T Y,Chang F R,et al. Lignans and kauranes from the stems of Annona cherimola[J]. J Chin Chem Soc,1998,45(5): 629.
[19]  Miyazawa M,Hisama M. Antimutagenic activity of phenylpropanoids from clove (Syzygium aromaticum)[J]. J Agr Food Chem,2003,51(22): 6413.
[20]  张援虎,胡峻,石任兵,等. 荆芥化学成分的研究[J]. 中国中药杂志,2006,31(13): 1118.
[21]  谭沛,刘永漋,侯翠英. 紫红獐牙菜中紫药苦苷的结构[J]. 药学学报,1993,28(7): 522.

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