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基于分子对接方法的川芎治疗脑缺血的物质基础及分子机制研究

Keywords: 川芎,分子对接,脑缺血

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Abstract:

川芎具有广泛的临床应用,是常用中药之一,但其有效物质及作用机制尚不明确。该研究优选川芎治疗脑缺血的有效成分,并探究其作用机制。选取4个与脑缺血相关的靶蛋白,以对应的上市药物为参照,基于分子对接技术对文献报道的川芎所含45种成分进行联合筛选。结果显示川芎中多个成分与靶点的对接结果优于对应的上市药物,如苯酞类物质,提示可能是川芎治疗脑缺血的主要有效成分。该方法可用于研究中药的物质基础和分子作用机制。

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