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塔中栽培荒漠肉苁蓉中的木脂素类成分

Keywords: 荒漠肉苁蓉,木脂素,化学成分,结构鉴定

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Abstract:

对新疆塔中栽培荒漠肉苁蓉Cistanchedeserticola干燥肉质茎的化学成分进行研究。采用多种色谱技术(正相硅胶、凝胶SephadexLH-20,MCI,ODS以及半制备高效液相色谱等)进行分离纯化,运用NMR、MS等波谱方法以及结合文献数据对分离得到的化合物进行结构鉴定。结果从塔中栽培荒漠肉苁蓉干燥肉质茎85%乙醇提取物中分离得到11个木脂素类化合物,其结构分别鉴定为:(+)-丁香脂素-4'-O-β-D-吡喃葡萄糖苷(1),(+)-isoeucomminA(2),(+)-麦奥迪脂素-4'-O-β-D-吡喃葡萄糖苷(3),(+)-松脂素单甲基醚-β-D-葡萄糖苷(4),落叶松脂醇-4'-O-β-D-葡萄糖苷(5),落叶松脂醇-4-O-β-D-葡萄糖苷(6),conicaoside(7),dehydrodiconiferylalcohol4-O-β-D-glucopyranoside(8),dehydrodiconiferylalcoholγ'-O-β-D-glucoside(9),橙皮素A(10),阿拉善苷A(11)。其中化合物1,3~7,10,11为首次从该属植物中分离得到,化合物2,8,9为首次从该植物中分离得到。

References

[1]  杨峻山. 沙漠人参——肉苁蓉[J]. 中国药学杂志, 2011, 46(12):881.
[2]  屠鹏飞, 姜勇, 郭玉海, 等. 肉苁蓉研究及其产业发展[J]. 中国药学杂志, 2011, 46(12):882.
[3]  张百顺, 赵学文, 陈双厚, 等. 肉苁蓉分离部位通便作用的实验研究[J]. 中国中医药信息杂志, 3003, 10(11):31.
[4]  郭红丽, 周金云. 青蛇藤正丁醇部分苷类成分的分离与鉴定[J]. 中国中药杂志, 2005, 30(1):45.
[5]  Sugiyama M, Kikuchi M. Studies on the constituents of Osmanthus species. Ⅶ. Structures of lignan glycosides from the leaves of Osmanthus asiaticus Nakai [J]. Chem Pharm Bull, 1991, 39(2):483.
[6]  Deyama T, Ikawa T, Nishibe S. The constituents of Eucommia ulmoides Oliv.Ⅱ. Isolation and structures of three new lignan glycosides [J]. Chem Pharm Bull, 1985, 33(9):3651.
[7]  Kitagawa S, Nishibe S, Benecke R, et al. Phenolic compounds from Forsythia leaves II [J]. Chem Pharm Bull, 1988, 36(9):3667.
[8]  Shoeb M, Jaspars M, MacManus S M, et al. Epoxylignans from the seeds of Centaurea cyanus(Asteraceae) [J]. Biochem Syst Ecol, 2004, 32(12):1201.
[9]  Sugiyama M, Kikuchi M. Characterization of lariciresinol glucosides from Osmanthus asiaticus [J]. Heterocycles, 1993, 36(1):117.
[10]  Fan C Q, Zhu X Z, Yue J M, et al. Lignans from Saussurea conica and their NO production suppressing activity [J]. Planta Med, 2006, 72(7):590.
[11]  Saracoglu I, Varel M, Calis I, et al. Neolignan, flavonoid, phenylethanoid and iridoid glycosides from Phlomis integrifolia [J]. Turk J Chem, 2003, 27(6):739.
[12]  Yoshizawa F, Deyama T, Takizawa N, et al. The constituents of Cistanche tubulosa(Schrenk) hook. f. Ⅱ. Isolation and structures of a new phenylethanoid glycoside and a new neolignan glycoside [J]. Chem Pharm Bull, 1990, 38(7):1927.
[13]  林生, 张中晓, 张卫东, 等. 菊叶千里光的一个新木脂素苷[J]. 中国中药杂志, 2011, 36(13):1755.
[14]  原忠, 周碧野, 李铣. 橙皮素A的NMR研究[J]. 波谱学杂志, 2002, 19(3):309.
[15]  Nan Z D, Zeng K W, Shi S P, et al. Phenylethanoid glycosides with anti-inflammatory activities from the stems of Cistanche deserticola cultured in Tarim desert [J]. Fitoterapia, 2013, 89:167.
[16]  南泽东, 赵明波, 姜勇, 等. 塔中栽培荒漠肉苁蓉化学成分研究[J]. 中国中药杂志, 2013, 38(16):2665.
[17]  中国药典. 一部[S]. 2010:126.
[18]  雷丽, 宋志宏, 屠鹏飞. 肉苁蓉属植物的化学成分研究进展[J]. 中草药, 2003, 34(5):473.
[19]  Jiang Y, Tu P-F. Analysis of chemical constituents in Cistanche species [J]. J Chromatogr A, 2009, 1216(11):1970.
[20]  吴晓春, 史颖. 肉苁蓉的研究与临床应用[J]. 甘肃中医, 2007, 20(12):49.
[21]  Pan J, Yuan C S, Lin C J, et al. Pharmacological activities and mechanisms of natural phenylpropanoid glycosides[J]. Pharmazie, 2003, 58(11):767.
[22]  Fu G M, Pang H H, Wong Y. Naturally occurring phenylethanoid glycosides:potential leads for new therapeutics [J]. Curr Med Chem, 2008, 15(25):2592.

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