Macrez R,Bezin L,Le Mauff B, et al. Functional occurrence of the interaction of tissue plasminogen activator with the NR1 Subunit of N-methyl-D-aspartate receptors during stroke[J].Stroke, 2010,41(12):2950.
[3]
王拥军.卒中:回眸2010[J].中国卒中杂志,2010,6(1):1.
[4]
Del Zoppo G J. Inflammation and the neurovascular unit in the setting of focal cerebral ischemia[J]. Neuroscience, 2009,158(3):972.
Yang Y, Rosenberg G A.Blood-brain barrier breakdown in acute and chronic cerebrovascular disease[J].Stroke,2011,42(11):3323.
[7]
G J del Zoppo. The neurovascular unit in the setting of stroke[J]. J Int Med,2010,156 (267):156.
[8]
Vivien D, Gauberti M, Montagne A, et al. Impact of tissue plasminogen activator on the neurovascular unit: from clinical data to experimental evidence[J].J Cereb Blood Flow Metab,2011,31(11):2119.
[9]
Liu R,Zhang T T, Wu C X, et al. Targeting the neurovascular unit: development of a new model and consideration for novel strategy for Alzheimer\'s disease[J]. Brain Res Bull,2011,86(1/2):13.
[10]
Gao M,Liu R,Zhu S Y,et al. Acute neurovascular unit protective action of pinocembrin against permanent cerebral ischemia in rats[J]. J Asian Nat Prod Res,2008,10(6):551.
[11]
Liu R, Gao M, Qiang G F, et al.The anti-amnesic effects of luteolin against amyloid beta(25-35) peptide-induced toxicity in mice involve the protection of neurovascular unit[J]. Neuroscience,2009,162(4):1232.
Shi L L,Chen B N,Gao M,et al.The characteristics of therapeutic effect of pinocembrin in transient global brain ischemia/reperfusion rats[J]. Life Sci,2011,88(11/12):521.
[14]
He X L, Zhou W Q, Bi M G, et al. Neuroprotective effects of icariin on memory impairment and neurochemical deficits in senescence-accelerated mouse prone 8 (SAMP8) mice[J]. Brain Res,2010,1334:73.
[15]
Dixon R M, Mellor J R, Hanley J G. PICK1-mediated glutamate receptor subunit 2 (GluR2) trafficking contributes to cell death in oxygen/glucose-deprived hippocampal neurons[J]. J Biol Chem,2009,284(21):14230.
[16]
He X L, Wang Y H, Gao M, et al.Baicalein protects rat brain mitochondria against chronic cerebral hypoperfusion-induced oxidative damage[J].Brain Res,2009,1249:212.
[17]
Liu R,Gao M,Yang Z H,et al.Pinocembrin protects rat brain against oxidation and apoptosis induced by ischemia-reperfusion both in vivo and in vitro[J].Brain Res,2008,1216:104.
[18]
Tan C B, Gao M, Xu W R, et al.Protective effects of salidroside on endothelial cell apoptosis induced by cobalt chloride[J].Biol Pharm Bull,2009,32(8):1359.
[19]
Liu R,Sun L,Huang C, et al.Anti-inflammatory activity of methyl salicylate glycosides isolated from Gaultheria yunnanensis (Franch.) Rehder[J]. Molecules,2011,16(5):3875.
[20]
Navon H, Bromberg Y, Sperling O, et al.Neuroprotection by NMDA preconditioning against glutamate cytotoxicity is mediated through activation of ERK 1/2, inactivation of JNK, and by prevention of glutamate-induced CREB inactivation[J]. J Mol Neurosci,2011.doi:10.1007/s12031-011-9532-4.
[21]
Du J, Wang Q, Hu B, et al.Involvement of ERK 1/2 activation in electroacupuncture pretreatment via cannabinoid CB1 receptor in rats[J].Brain Res,2010,1360:1.
[22]
Lu S, Lu C, Han Q, et al.Adipose-derived mesenchymal stem cells protect PC12 cells from glutamate excitotoxicity-induced apoptosis by upregulation of XIAP through PI3-K/Akt activation[J]. Toxicology,2011,279(1/3):189.
[23]
Liu R,Zhang L, Lan X, et al.Protection by borneol on cortical neurons against oxygen-glucose deprivation/reperfusion: involvement of anti-oxidation and anti-inflammation through nuclear transcription factor kappaB signaling pathway[J].Neuroscience,2011,176:408.
[24]
Asahi M,Wang X,Mori T,et al. Effect of matrix metalloproteinase 9 gene knockout on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia[J]. J Neurosci,2001,21(19) :7724.
[25]
Gomes J R, Lobo A C, Melo C V, et al.Cleavage of the vesicular GABA transporter under excitotoxic conditions is followed by accumulation of the truncated transporter in nonsynaptic sites[J].J Neurosci,2011,31(12):4622.
[26]
Rutkowsky J M, Wallace B K, Wise P M, et al. Effects of estradiol on ischemic factor-induced astrocyte swelling and AQP4 protein abundance[J].Am J Physiol Cell Physiol,2011,301(1):C204.
[27]
Chang D I,Hosomi N,Lucero J. Activation systems for latent matrix metalloproteinase-2 are upregulated immediately after focal cerebral ischemia[J]. J Cereb Blood Flow Metab,2003,23:1408.
[28]
Croll S D,Wiegand S J. Vascular growth factors in cerebral ischemia[J]. Mol Neurobiol,2001,23:121.
[29]
Hopkins A L.Network pharmacology: the next paradigm in drug discovery [J]. Nat Chem Biol,2008,4:682.
[30]
Orsucci D,Calsolaro V,Mancuso M, et al. Neuroprotective effects of tetracyclines: molecular targets, animal models and human disease[J].CNS Neurol Disord Drug Targets,2009,8(3):222.