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盐酸小檗碱自组装小珠载药系统的制备与体外评价

Keywords: 小珠,α-环糊精,大豆油,盐酸小檗碱,自组装给药系统,脂质制剂

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Abstract:

该文主要研究一种使用α-环糊精和大豆油在室温下连续振荡即可制得的自组装小珠给药系统,在制备过程中不需要使用任何表面活性剂或有机溶剂.以盐酸小檗碱为模型药物,对制备的小珠进行形态、结构、载药量、体外释药行为考察.药物的负载方法为制备之前溶解于大豆油中,小珠粒径为(2.25±0.23)mm,载药量为(67.02±0.64)μg·g-1.荧光标记后激光共聚焦显微镜观察显示,小珠为核壳结构,水难溶性药物主要分布在大豆油内核中.小珠在模拟肠液中的释药速率和累积释药量均显著高于原料药.这表明小珠是一种适用于水难溶性中药的有发展潜力的脂质新剂型.

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